Was Doing OK Then . . . No Go

Anything goes when it comes to ED.
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Stew52
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Location: Central TX

Was Doing OK Then . . . No Go

Postby Stew52 » Tue Jan 02, 2024 6:03 pm

I was doing very good with 0.50 ml of 80 mcg/ml PGE injections then - bam - it started not working so well. Neurologist had put my on 1200mg/dy gabapentin, 16mg tizanidine (muscle relaxer) and some Celebrex for PN and radiated pain into my legs from my lumbar back issues (radiculopathy).

Comments here are mixed on gaba impacts and could find nothing on muscle relaxers. Yes, NSAID's impact orgasm but I already have bad anorgasmia.

TIA for insights, B
Last edited by Stew52 on Wed Jan 03, 2024 9:22 am, edited 1 time in total.
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

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bldoink
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Re: Was Doing OK Then . . . No Go

Postby bldoink » Wed Jan 03, 2024 2:03 am

I'd be concerned about all three drugs. Plus I think all three are not friends of your liver.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Nerve sparing - damaged. C in margin. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 12 yrs. It works. Treasure coast of FL.

Pumpkinman
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Re: Was Doing OK Then . . . No Go

Postby Pumpkinman » Wed Jan 03, 2024 7:11 am

It doesn't sound like its the injections not working all of a sudden but the other combination of medications messing with your system.

Old Guy
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Re: Was Doing OK Then . . . No Go

Postby Old Guy » Wed Jan 03, 2024 9:36 am

Sorry for the sudden no go. Any drug has some sort of side effect. Unfortunately, it sounds like your doc put you on some meds that affect more than they fix. Talk to the doc and see if there are other meds with fewer side effects.
Nov. 8, 2019
4+ years, Coloplast Titan OTR
Married 36 years to my beautiful young bride
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Stew52
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Location: Central TX

Re: Was Doing OK Then . . . No Go

Postby Stew52 » Mon Jan 08, 2024 1:13 pm

Yea, gabapentin "less common" side effect is "inability to have or keep an erection". Have tried Cymbalta and Lyrica already which had worse side-effects for me. SO time to wane off gaba and see just how bad the legs and PN hurts. Ugh.
Last edited by Stew52 on Sun Feb 04, 2024 10:04 am, edited 1 time in total.
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

Martin6469
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Re: Was Doing OK Then . . . No Go

Postby Martin6469 » Mon Jan 08, 2024 2:30 pm

Stew: Years ago, before old age anorgasmia set in, I took gabapentin at a lower dose than you and it caused severe anorgasmia, which disappeared when I went off it. Maybe you can schedule sex days and go off it maybe 48 hours ahead.

The gaba had no effect on my sildenafil erection.
Age 78 in 2023. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.

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Stew52
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Location: Central TX

Re: Was Doing OK Then . . . No Go

Postby Stew52 » Sun May 26, 2024 6:04 pm

So I got off all the nerve drugs, only do a very small ACEI dose. Been injecting for 7 1/2 yeas with good success but an increasing dose over time.

But as per above, I found my reaction to a stronger dose (0.6ml or 60 units) of strong mix (80mcg PGE+) was fading. It wasn't as hard, didn't last as long, and there was far less burn. It seemed to drop off pretty quickly.

I supplement with 1-2 10mg Cialis. As for assistance, I've been doing 2x EndoPeak sex herbs, L-Arginine, L-CItruline, Ginko, a nitric oxide promoter NEO40 and Niacin. I've been doing VED regularly (great girth), mild jelquing, and regular sex. The unit's appearance was good. But . . .

But still response to the stronger injection was fading.

So I indented for a Phoenix "shock-wave" therapy device. Did my first month, a month "rest" from it and VD 2x a day as recommended, and just started my 2nd series.

It 's early days yet, but seems to be working. Actually got insertion and thrusting without a injection for the first time in a long time, but I did one anyway at a break to last longer and thrill my bride. SO far, I can use less injectable, it lasts longer, it stays harder, on the downside the refractory period is longer, and the burn is back, all like several years ago after I started injecting with great success.

I've always thought the burn was bad juju. Anything that burns can't be good, but it came with the package. My theory is that the chemical(s) were scarring the cavernosa and over time it was getting more "immune" to the drug. Hence increasing the dose slowly over time. The Phoenix device induces tissue healing by stimulating a naturally induced healing and stem cell response. I theorize that the damaged tissue is healing and is now again more susceptible to the chemicals reaction, as well as in general improvement in function. I also note bigger veins popping out and longer flaccid length (girth from VED is great). Phoenix says in my inquiry that it will not fix venous leakage, but I just want the injection to work as it has in the past. So, so far, so good. They say the 2nd round is the money shot so I'll report out in a while.
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.


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