In February my urologist started me with a very strong formula of Trimix 40/30/2. This is my first Trimix and 4 units has been working great.
I'm almost done with the 10 ml bottle and getting ready for a refill.
My concern is that if I keep going with this strong formula and my body gets used to it I have no other option but Quadmix and after I'm done with that implant.
Should I try aprostadil, bimix or a weaker formula of Trimix?
Should I change my Trimix formula?
Should I change my Trimix formula?
Age 54, Single, Los Angeles. Stage 2 rectal cancer in 2013. Radiation, surgery, chemo. In remission for 5 years. Some ED before cancer, complete since. 2-3 units of Trimix 40/30/2 2-3 times a week since Feb/2017 with great success!
Re: Should I change my Trimix formula?
If that formula is working well for you I see no reason to change the potency. That's apparently the correct amount of the actual meds for you. If you got a formula that was half as strong you'd just have to use twice as much. I may be wrong but I don't think your body, as far as developing resistance, is going to care if you're taking the same amount of meds suspended in 4 units of saline or 8. Injecting the more concentrated mix slower may be worthwhile to reduce tissue shock but then it might not matter either. Maybe I'll remember to ask my doctor to validate my theory but I'll probably forget.
The only way I'd change it up would be if your formulas were completely custom, although I understand most of the pharmacies just have several set formulas for your doctor to choose from. If totally custom I personally would be interested in trying a lower ratio of papaverine. But darn, what you're using is working. Do you want to mess with success?
OK, many here won't agree with me on this. IMHO, since you obviously don't have a major issue with alprostadil (based on your script and results) I would consider trying straight alprostadil. It supposedly does not work as well as the tri-mix, although it's generally considered the most effective ingredient of tri-mix. However, one of the major ingredients of tri-mix, papaverine, is, according to my understanding, the drug most likely to cause peyronies disease. Switching to straight alprostadil might reduce the peyronies risk and would then leave tri-mix there for you to fall back on if the alprostidil begins to be less effective. I'm not trying to scare you and I would readily use tri-mix if the alprostadil didn't work so well for me but you asked and that's my humble layman's opinion. It's probably not a major concern though. It's my understanding that tri-mix or injection caused peyronies is actually fairly rare.
The only way I'd change it up would be if your formulas were completely custom, although I understand most of the pharmacies just have several set formulas for your doctor to choose from. If totally custom I personally would be interested in trying a lower ratio of papaverine. But darn, what you're using is working. Do you want to mess with success?
OK, many here won't agree with me on this. IMHO, since you obviously don't have a major issue with alprostadil (based on your script and results) I would consider trying straight alprostadil. It supposedly does not work as well as the tri-mix, although it's generally considered the most effective ingredient of tri-mix. However, one of the major ingredients of tri-mix, papaverine, is, according to my understanding, the drug most likely to cause peyronies disease. Switching to straight alprostadil might reduce the peyronies risk and would then leave tri-mix there for you to fall back on if the alprostidil begins to be less effective. I'm not trying to scare you and I would readily use tri-mix if the alprostadil didn't work so well for me but you asked and that's my humble layman's opinion. It's probably not a major concern though. It's my understanding that tri-mix or injection caused peyronies is actually fairly rare.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Nerve sparing - damaged. C in margin. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 12 yrs. It works. Treasure coast of FL.
Re: Should I change my Trimix formula?
Newtoed --
The guys on Frank Talk can give you the benefit of our experience. And that experience is information that can be helpful and provide excellent perspective. At the same time, medical advice should come from your urologist. I'm not trying to make a big thing about it, but the doc should have the first word and the final word. Just my opinion. If the doc you have is not solving the problem, then maybe it's time for a new doctor. I know that's not always an easy option in some circumstances, but I do believe it's the best option. Here's to hard times.
The guys on Frank Talk can give you the benefit of our experience. And that experience is information that can be helpful and provide excellent perspective. At the same time, medical advice should come from your urologist. I'm not trying to make a big thing about it, but the doc should have the first word and the final word. Just my opinion. If the doc you have is not solving the problem, then maybe it's time for a new doctor. I know that's not always an easy option in some circumstances, but I do believe it's the best option. Here's to hard times.
Born 1948, wed 1969. BPH & Type II Diabetes at age 35. TURP-2002; ED even before that--diabetes. Cardiac valve surgery: 2007 & 2019. Poor results with pills. Started trimix injections in Nov, 2010. Great results from the very beginning.
Re: Should I change my Trimix formula?
antelope,
I can only agree with you 80 to 90 % or thereabouts. First off, nothing I say should ever be considered medical advice and anything I say that conflicts with a doctor should be quickly disregarded. That probably also applys to anything read on this forum. Always consult with your doctor. I think that was probably your main and very valid point with which I totally agree.
However, if I read something on this forum that is of interest I won't hesitate to ask my doctor about it, and I have. As for trusting your doctor first and last. No I don't think so. I'll trust them but not totally and I'll trust them with my life (and dick) reluctantly and only when necessary. I'll also question them if I feel the urge.
Most doctors I've had don't mind being questioned and know enough about medical mistakes to understand. If they have too much ego for that I don't want them. Doing your own research (this forum could be part of that), questioning the doctor and getting second opinions with serious stuff is just being smart IMHO. I got a second opinion before my RP. I totally trust no man except the one that is also God. The doctors aren't gods.
It was illuminating when I was banished to Courthouse Security, when I was slow recovering from knee surgery, to be assigned to a civil trial. Low and behold my ortho, considered one of the best and who had done my knee surgery about 40 days prior, shows up in court with another doctor, both getting sued for causing the amputation of a teens leg. Yeah they did royally screw up on that kid. I do think he did fine on my knee but the situation was a bit strange, and me limping around the courtroom on work he'd done.
Sorry about the thread hijack.
I can only agree with you 80 to 90 % or thereabouts. First off, nothing I say should ever be considered medical advice and anything I say that conflicts with a doctor should be quickly disregarded. That probably also applys to anything read on this forum. Always consult with your doctor. I think that was probably your main and very valid point with which I totally agree.
However, if I read something on this forum that is of interest I won't hesitate to ask my doctor about it, and I have. As for trusting your doctor first and last. No I don't think so. I'll trust them but not totally and I'll trust them with my life (and dick) reluctantly and only when necessary. I'll also question them if I feel the urge.
Most doctors I've had don't mind being questioned and know enough about medical mistakes to understand. If they have too much ego for that I don't want them. Doing your own research (this forum could be part of that), questioning the doctor and getting second opinions with serious stuff is just being smart IMHO. I got a second opinion before my RP. I totally trust no man except the one that is also God. The doctors aren't gods.
It was illuminating when I was banished to Courthouse Security, when I was slow recovering from knee surgery, to be assigned to a civil trial. Low and behold my ortho, considered one of the best and who had done my knee surgery about 40 days prior, shows up in court with another doctor, both getting sued for causing the amputation of a teens leg. Yeah they did royally screw up on that kid. I do think he did fine on my knee but the situation was a bit strange, and me limping around the courtroom on work he'd done.
Sorry about the thread hijack.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Nerve sparing - damaged. C in margin. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 12 yrs. It works. Treasure coast of FL.
Re: Should I change my Trimix formula?
I have read several articles and I believe it's also on Dr. Eid's site ( he's the Doc a lot guys have gone to on this site for an implant) that you don't develop a resistance to Trimix, but the underlying medical condition causing the ED gets worse and that's why guys usually have to increase the dose or the formula. This coming February I will be injecting 5 years..and outside of a little scare concerning scar tissue Trimix has been a godsend...My dose has increased but interestingly enough my formula has been reduced....great results but no ache...BTW I am a 63 yr old with cardiovascular disease...cardiac by-pass March 2012...another kind of funny note...cardiologists get better results with keeping men on low cholesterol low fat diets, exercise regiments, etc by telling them it's good for your erections..Good Luck to you..
69 year old legally separated retired health-care professional. ED began in my early 50's. Viagra worked great for about 5 years, then had cardiac by-pass surgery and eventually moved to injections about 10 years ago.
Re: Should I change my Trimix formula?
bldoink
No worries. Given some cold beer and plate of nachos, I'd bet we'd end up at 99%.
And to clarify, I certainly don't think doctors are perfect. As I stated, if the one you have is not solving the problem, then hire a new one. I do understand that choosing a new doctor may not be practical in all cases and jurisdictions, but it's still a relevant point.
I still think that we need to make it clear that we are not offering medical advice. We do that well and pretty consistently, but it seems that not everyone gets the message. At least that's what I deduce from certain word choices and phrasing.
All the best.
No worries. Given some cold beer and plate of nachos, I'd bet we'd end up at 99%.
And to clarify, I certainly don't think doctors are perfect. As I stated, if the one you have is not solving the problem, then hire a new one. I do understand that choosing a new doctor may not be practical in all cases and jurisdictions, but it's still a relevant point.
I still think that we need to make it clear that we are not offering medical advice. We do that well and pretty consistently, but it seems that not everyone gets the message. At least that's what I deduce from certain word choices and phrasing.
All the best.
Born 1948, wed 1969. BPH & Type II Diabetes at age 35. TURP-2002; ED even before that--diabetes. Cardiac valve surgery: 2007 & 2019. Poor results with pills. Started trimix injections in Nov, 2010. Great results from the very beginning.
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