Bupropion

The final frontier. Deciding when, if and how.
Osprey_1
Posts: 94
Joined: Tue Jan 28, 2025 10:06 pm

Bupropion

Postby Osprey_1 » Sun Oct 12, 2025 8:51 pm

After 6 months, I am still unable to have a PIV orgasm and struggle to achieve orgasm with a hand job. My dick is still numb. I’ve read that Bupropion can hel
With orgasm achievement. Is there any one out there that has been prescribed Bupropion for this purpose? Result?
69 years old. Prostate cancer followed by radiation. Implanted with Titan with classic pump on 3/24/2025.

lasthope2.0
Posts: 6
Joined: Sat Oct 11, 2025 1:23 pm

Re: Bupropion

Postby lasthope2.0 » Sun Oct 12, 2025 9:25 pm

I was prescribed Caborgoline for this purpose. It's a dopamine promoter and it didn't help.

UpNorth
Posts: 221
Joined: Wed Apr 30, 2025 3:40 pm

Re: Bupropion

Postby UpNorth » Sun Oct 12, 2025 9:42 pm

I’ve taken Bupropion for a couple years, just started a new RX, once daily.
I rarely have orgasms easily, but hurray I had three in last 24 hours, I doubt it’s from the Bupropion. It’s from intense hardcore sex. Also I may add I’ve hit the gym since Aug 8 and six days a week since Sept 4.
There is another thread going on about lack of orgasms I see your in it as well. I’ll probably post something there tomorrow. It’s late.
Chat later.
62. ? Asked. What is your sex life like? I’m a Romantic She’s a Nymphomaniac.
Coloplast Titan IPP
NYC by The Man The Myth The Legend Dr Eid
Penoscrotal W/ Scrotoplasty
Friday the 13th of June, 2025
Ed due to chronic pain, arterial insufiency, etc.

CanGetItUpButNotOff
Posts: 377
Joined: Mon Sep 20, 2021 1:34 pm

Re: Bupropion

Postby CanGetItUpButNotOff » Tue Oct 14, 2025 1:27 am

I've been taking 75 mg for about 3 months. I can't say for sure that it has helped but I have seen some improvement in that timeframe. Other factors may be at work but I'm giving the benefit of the doubt to Bupropion and continuing - even moving up to 150mg to see if that is even better.
Born 1954. Diabetes, hypertension, atherosclerosis. Sildenafil iffy. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend pending long-term efficacy. Daily Cialis. Tried LiESWT 4 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy

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GoodWood
Posts: 1301
Joined: Sun Jun 16, 2019 1:07 pm

Re: Bupropion

Postby GoodWood » Tue Oct 14, 2025 7:32 am

A few years ago my urologist put me on 150mg of Buproprion XL (extended release) to try to lower the threshold to orgasm.

It didn’t make a difference.

Then we went to 300mg.

It didn’t make a difference.

Then we went to 450mg.

It didn’t change anything about my orgasms. I did feel a bit better overall. I never considered taking antidepressants. Never thought it was something I needed. But I liked that I felt like I had some extra spring in my step so I’ve continued it since.
57yo, NYC. ED started at 40. Pills, then shots for 10 years. 24cm Coloplast Titan XL w/classic pump by Dr Eid 3/25/2025. Will meet for show & tell.
Implant journal: [url] viewtopic.php?f=6&t=26225[/url]

Rider1400
Posts: 1196
Joined: Sun Dec 06, 2020 4:23 pm
Location: Benton Arkansas

Re: Bupropion

Postby Rider1400 » Tue Oct 14, 2025 9:31 am

I have struggled with inorgasmia since my ED began back 15 years ago. However it does seem that after the first year or so with the implant things have gotten a little more consistent but still require a LOT of effort to finish.
In last year I’ve been using a prostate stimulation toy while having sex which has made a massive difference. Actually wait sometimes til I think the timing is right to use the toy as it generally makes things come to an end within 5 min or so.
Also think that with all the stimulation I needed prior to implant and prior to injections that I could have been stressing the nerves a bit in my dick. Also think injections probably strained things a lot as when the injections worked they worked extremely good and would get so hard that it almost hurt in a good kind of way. Then in the 4 months prior to implant I used a VED twice daily for 30 min and I know for sure my orgasms were lacking greatly during this time. All said probably overuse and lots of stress didn’t help. Maybe why after a year with implant and getting into a more relaxed routine of sec twice a week has given my dick a little time to heal the nerves
59 years old ED started mid 40s pills failed after 10 years. Injections works but diminishing results with pain. Implanted 5-22 Baylor,Scott,and White Dallas.Dr Michael Wierschem, infrapubic Coloplast with Classic pump 20cm and 1cm RTE. Going strong

cbinspok
Posts: 840
Joined: Wed Feb 03, 2021 7:45 pm

Re: Bupropion

Postby cbinspok » Tue Oct 14, 2025 10:04 am

Upnorth. Touched on an issue that get little attention on our site, keeping in shape. Staying HWP isn’t easy but is so important for all of us. Hitting the even for get the routine down is a great idea. Im there nearly every day and watch my weight. Everything follows that. Good luck on the cummming your brain has to be in the right place too. Hoping you find your loads. Hugs
67years,fighting ed for over twenty years. A sever break, vit E, pataba, Viagra, massage Ved cilas, and I'm tired- throwing in the towel, Op for implant Mar 18, 2021 AMS LGX 18 x12 + 1 3cm RTE, gained girth and length, very glad I took the hard step.


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