Is My Mix Going Bad, Or Am I More Tolerant?

Sticking a needle Where? Courage, guidance and help.
ragnar35
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Joined: Tue Jan 23, 2018 12:35 pm
Location: Tampa

Is My Mix Going Bad, Or Am I More Tolerant?

Postby ragnar35 » Mon Apr 02, 2018 2:08 pm

I went from a bimix that wasn't working well, to a TriMix (10/30/1) several months ago. The first time I tried the Trimix, it hurt a fair amount, and it felt like my penis weighed 10 pounds (injecting 20). I tried less, but it wasn't effective.

Then I tried doing 10 of the trimix, and 50 of the bimix, and it worked fairly well at first. Gradually, it became less effective. Last night, I used 30 of the trimix - the erection before orgasm was 3/4. The erection after orgasm was fully rigid.

Is it possible that the mix has lost its effectiveness while sitting in my refrigerator? Is it possible I am building a tolerance to the drug in the trimix?
57 years old, male, low-grade prostate cancer being monitored, ED for 40 years, injecting Papaverime/Phentol 30/1 - but switching to a trimix to see if i get a better result.

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bldoink
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Location: Fl.

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby bldoink » Mon Apr 02, 2018 5:06 pm

The big gun of tri-mix, which is alprostadil, will lose it's effectiveness when refrigerated after about 3 days. My experience has been that the alprostadil will stay effective, when well frozen, for 6+ months. My prescription label says 45 days when frozen, 3 days refrigerated. That's just my experience with my meds (mono-mix which is just alprostadil and saline) and my pharmacy. It may not apply to you. Consult you doctor and/or pharmacist. My pharmacist advises he's not allowed to tell me it will last 6 months when frozen. He doesn't say it won't either.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.

Cigar56
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Joined: Fri Aug 15, 2014 10:56 am

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby Cigar56 » Mon Apr 02, 2018 7:49 pm

It just depends. I have some Trimix that I have kept entirely in the refrigerator for seven months. On a scale of 1-10 I would say the effectiveness right now is a 7 or 8 -- no bad for never being frozen.
I've tried everything -- pills, injections pumps -- and now I am at the final frontier.

tomas1
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Joined: Tue Jul 23, 2013 5:12 pm
Location: Tempe, AZ

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby tomas1 » Mon Apr 02, 2018 8:27 pm

I know in my case I'm getting somewhat immune to Quad-mix. I'm using a pretty strong formula with 100 PGE and take 35 units now. I can see the possibility of it not working at all, and that presents a problem
85 years
Inject testosterone weekly.
Implant on 1/22/19 by Dr Avila.
Scrotal, hor. incision just over 1"
18cm AMS 700 CX, 3.5cm RTE 100cc res
Gleason 6 prostate cancer. Monitoring it for now.
Update: On my last biopsies the cancer wasn't found.

oldbeek
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Location: Los Angeles area

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby oldbeek » Mon Apr 02, 2018 11:29 pm

My frozen trimix is 6 months old. I only use 1 unit. Still very effective.
82, good health, RP 7-2017, all nerves taken , PSA 0.05, 4-18,, .07 1/19,.05 4/19, .03 11-21, .04 11-23, implanted 4-1-18, Infra-pubic, AMS lgx 15 cm with 5cm rte. Implant at USC Keck. Dr Boyd and Dr Loh Doyle 6.5 x 5, 800 AUS 7-21-20

ragnar35
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Joined: Tue Jan 23, 2018 12:35 pm
Location: Tampa

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby ragnar35 » Tue Apr 03, 2018 9:54 am

The instructions with my med say to refrigerate at 36 - 42 degrees. The vile i receive is one 5ml vile - wouldn't that break if I froze it? If not - how long does it take to thaw? You really have to plan - but if freezing keeps its potency, I suppose I will have to try it.

Thanks,
57 years old, male, low-grade prostate cancer being monitored, ED for 40 years, injecting Papaverime/Phentol 30/1 - but switching to a trimix to see if i get a better result.

Larry10625

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby Larry10625 » Tue Apr 03, 2018 10:22 am

ragnar35 wrote:The instructions with my med say to refrigerate at 36 - 42 degrees. The vile i receive is one 5ml vile - wouldn't that break if I froze it? If not - how long does it take to thaw? You really have to plan - but if freezing keeps its potency, I suppose I will have to try it.

Thanks,



I pre-filled my syringes and stored them in the freezer in a Ziploc baggie. Then, when I needed one I would take only one outta the freezer and thaw it. That way I did not have to thaw all of it and refreeze over and over again. :)

Larry

kilsong
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Joined: Fri Sep 28, 2012 3:17 pm

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby kilsong » Thu Apr 05, 2018 4:25 pm

bldoink wrote:The big gun of tri-mix, which is alprostadil, will lose it's effectiveness when refrigerated after about 3 days.

Huh?
I've been using Trimix for about 3 years and have had each vial for about 2 months in the fridge--not the freezer-- and it's worked each time.

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bldoink
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Location: Fl.

Re: Is My Mix Going Bad, Or Am I More Tolerant?

Postby bldoink » Thu Apr 05, 2018 4:44 pm

The pharmacist label was suggesting 3 days. This study referenced below suggests a longer refrigerated life but it's still the most perishable component.

Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction.
Trissel LA1, Zhang Y. An abstract: https://www.ncbi.nlm.nih.gov/pubmed/23924676
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.


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