Page 1 of 1
does refrigeration damage liquid phenylephine
Posted: Sat May 03, 2025 6:17 pm
by Budward
Just wondered when I first ordered my Trimix they send a vial of liquid phenylephine. I refrigerated it without reading the label say "Do not refrigerate". Does this mean it is no good now?
Re: does refrigeration damage liquid phenylephine
Posted: Sun May 04, 2025 10:14 pm
by CanGetItUpButNotOff
I have two bottles of phenylephrine. One has labeling to refrigerate (from MenMD); the other says not to refrigerate (from Olympia) my best guess - and that's all it is - is that each pharmacy has a different compounding process that either is or is not sensitive to temperature..
I'm not a doc or a pharmacist, but I find it difficult to believe cooling would hurt the compound. Hopefully someone with expertise will chime in.
Re: does refrigeration damage liquid phenylephine
Posted: Mon May 05, 2025 4:05 am
by Rosuf5
I have no medical expertise, but I am a chemical engineer. Very few materials are negatively impacted from cold temperatures. Some materials however can be negatively impacted from freeze thaw cycles so my speculation would that is what they are trying to avoid by saying to not refrigerate. If it just got cold my two cents would be you have noting to worry about.
Re: does refrigeration damage liquid phenylephine
Posted: Mon May 05, 2025 12:25 pm
by Budward
Rosuf5 wrote:I have no medical expertise, but I am a chemical engineer. Very few materials are negatively impacted from cold temperatures. Some materials however can be negatively impacted from freeze thaw cycles so my speculation would that is what they are trying to avoid by saying to not refrigerate. If it just got cold my two cents would be you have noting to worry about.
Hopefully I won't have to use it but tirating a new batch of stronger Trimix so a bit concerned, going to inject a very low dose the first time (today).
Re: does refrigeration damage liquid phenylephine
Posted: Sat May 10, 2025 1:12 pm
by Budward
injected just over 1.0 which is over half of what I was taking. Got a great erection and lasted only an hour. Got great advice here on Franktalk. One guy said to buy the stronger script of Trimix as the cost of compounding the same for all strengths. So I will see how many injections I get from the new vial and see what the average cost per injection is. Will let you all know.
Re: does refrigeration damage liquid phenylephine
Posted: Sat May 10, 2025 3:23 pm
by GoodWood
Budward wrote:injected just over 1.0...
Hey Budward. Injected over 1.0 what? 1 unit? That would be a TINY amount to measure. Nearly impossible actually.
1.0 cc or ml? That would be 100units and an ENORMOUS dose. In that were the case I would ask the urologist to make it SEVERAL steps stronger so you can get the volume of fluid you inject into the 10-15 unit range. That was big enough to have a reasonable level of precision when measuring it, yet small enough that I got lots of doses out of a vial.
Anyways, units is important to get meaningful advice. And putting your Trimix prescription in your signature is helpful as well: PGE (prostaglandins) mcg, Papaverine mg, Phentolamine mg. That helps too.
Re: does refrigeration damage liquid phenylephine
Posted: Sat May 10, 2025 4:28 pm
by bldoink
GoodWood wrote:Hey Budward. Injected over 1.0 what? 1 unit?
I'm betting he meant 10 units or 0.1ml
Re: does refrigeration damage liquid phenylephine
Posted: Sun May 11, 2025 7:01 am
by CanGetItUpButNotOff
GoodWood wrote:Budward wrote:injected just over 1.0...
Hey Budward. Injected over 1.0 what? 1 unit?
Same question.
GoodWood wrote:Budward wrote:injected just over 1.0...
… I would ask the urologist to make it SEVERAL steps stronger so you can get the volume of fluid you inject into the 10-15 unit range. That was big enough to have a reasonable level of precision when measuring it, yet small enough that I got lots of doses out of a vial.
I wouldn't advise my strategy to anyone because it is fraught with risks. But what I do, is to dilute my mix 3:1 with bacteriostatic water, so that what I inject is actually four times the volume than the Rx says. E.g. 2 actual iu's is 8 in the syringe.