FrankTalk.org

Hello All

i am currently takin trimix which works perfectly at the lower dose. i would like to swtich to bimix or alprostodil only injection since i would like to reduce scarring risk and also minimize inconvenience of refrigeration.

what are my options? is it caverject or edex? please advise

are these more expensive than trimix?

roy123 wrote:Hello All

i am currently takin trimix which works perfectly at the lower dose. i would like to swtich to bimix or alprostodil only injection since i would like to reduce scarring risk and also minimize inconvenience of refrigeration.

what are my options? is it caverject or edex? please advise

are these more expensive than trimix?

1) I don't think bimix will reduce the risk of scarring.

2) Switching to alprostadil will not reduce the need for refrigeration. It will increase it as the alprostadil is the most perishable ingredient.

3) Unless you are fully covered by insurance both Caverject and Edex will be much more expensive.

4) If what you're doing now works perfectly at a very small dose I think I'd just stick with that. If it ain't broke, don't fix it!

roy123 wrote:Hello All

i am currently takin trimix which works perfectly at the lower dose. i would like to swtich to bimix or alprostodil only injection since i would like to reduce scarring risk and also minimize inconvenience of refrigeration.

what are my options? is it caverject or edex? please advise

are these more expensive than trimix?

I have been using Trimix well over a decade, and have no scarring, confirmed by ultrasound. Any time you put a needle into your cavernosa you risk scarring. I think it's more than mechanical action that is the risk, not the medication.

ElbowRoom wrote:Any time you put a needle into your cavernosa you risk scarring. I think it's more than mechanical action that is the risk, not the medication.

I am in search of the answer to this question. I've asked three different urologists and one said it was the drug; two said it was the mechanical action of the needle.

bldoink wrote:

roy123 wrote:Hello All

i am currently takin trimix which works perfectly at the lower dose. i would like to swtich to bimix or alprostodil only injection since i would like to reduce scarring risk and also minimize inconvenience of refrigeration.

what are my options? is it caverject or edex? please advise

are these more expensive than trimix?

1) I don't think bimix will reduce the risk of scarring.

2) Switching to alprostadil will not reduce the need for refrigeration. It will increase it as the alprostadil is the most perishable ingredient.

3) Unless you are fully covered by insurance both Caverject and Edex will be much more expensive.

4) If what you're doing now works perfectly at a very small dose I think I'd just stick with that. If it ain't broke, don't fix it!

thanks for your reply. i read somewhere that caverject can be obtained in powdered form hence no refrigeration. i may be getting confused here. also i heard that 2 other ingredients in trimix besides alprostodil essentially increases the scarring risk.

roy123 wrote:thanks for your reply. i read somewhere that caverject can be obtained in powdered form hence no refrigeration. i may be getting confused here. also i heard that 2 other ingredients in trimix besides alprostodil essentially increases the scarring risk.

Yes, both Caverject and Edex come in cartridges with saline and dry alprostadil that you mix in the cartridge before use. Yes they are very shelf stable at normal room temperature. It's pretty handy stuff to have for traveling. However, unless you have very good insurance they are also very expensive and even if covered by insurance they will be rationed.

Pre-mixed alprostadil from a compounder is the most perishable of the tri-mix ingredients and should be refrigerated and probably frozen. There is some studies that indicate that the other ingredients of tri-mix or bi-mix pose a higher likelihood of causing fibrosis than that posed by alprostadil alone. But none are risk free. Many guys use tri-mix for years without problems. You stated you were on a very small dose of tri-mix and it was working perfect.

You stated you were interested in 1) convenience, 2) no refrigeration issues, 3) economy, 4) safety and I'll assume 5) continued efficacy. I don't believe at this point there is a drug that provides all 5. It's just my opinion but I think you are currently using the option that is closest to your goal.

I'm a big believer in straight compounded alprostadil, for me. That doesn't mean it's the best option for everyone. If not for your concern about expense and assuming you can be satisfied with the limited doses generally allowed by insurers, I'd say go for the Edex or Caverject.

Bi-mix contains the ingredient most likely to be of concern for causing fibrosis and there would be more of it to compensate for the lack of alprostadil, the heavy hitter of the bunch. But with fewer refrigeration concerns.

While requiring some refrigeration, not necessarily required by the bi-mix, tri-mix seems to have less refrigeration concerns than compounded alprostadil. You said you're on a small dose of tri-mix so I'm guessing that would reduce your fibrosis concerns.

I love my compounded alprostadil because it's very effective for me, and it's very affordable for as many doses as I have a use for, and potentially less fibrosis risk. But it needs the refrigeration more than the other options.

Good luck with your decision. All are viable choices.