Is trimix made differently among pharmacies?

[ElbowRoom]

Trimix is not a single formula, it's more a class of drug that contains the three different medications. Each compounding pharmacy has its own formulation with its own proportions of the three. If you ever change pharmacies look at the new label and compare it to the old one. If the doses of the three drugs are different, you need to start again with a small dose and titrate up to find your correct dose for that formulation. It's a pain in the ass, but compounded drugs aren't standardized so you have to have some more caution with them.

As to life of the drug...most say 90 days if kept refrigerated, but some might say 60 or 30. I have used Trimix almost a year old that has been refrigerated with no issues or loss of efficacy. Just shake it up a little each time, and check if it's clear. If it's cloudy just toss it to be safe. My urologist's PA confirmed to me "yeah it says 90 days, but if it's refrigerated it's closer to 'indefinite'."

[ElbowRoom]

If you ever change pharmacies look at the new label and compare it to the old one. It's a pain in the ass, but compounded drugs aren't standardized

As to life of the drug...most say 90 days if kept refrigerated, but some might say 60 or 30. I have used Trimix almost a year old that has been refrigerated with no issues or loss of efficacy.

Hi.. Appreciate the input. Would you please answer my questions in my thread here? It's very important.

viewtopic.php?f=5&t=26375&p=251733#p251733

I posted in that thread. Is there a specific question you have that didn't get answered?

[ElbowRoom]

I posted in that thread. Is there a specific question you have that didn't get answered?

Yeah I do have a specific question. Will 2 trimixes from 2 different pharmacies have differences in effectiveness? Would I have to adjust the dosage?

I ask cuz in a trimix from a previous pharmacy years ago I injected 3 units to get erect. With a trimix from a current pharmacy I need to inject like 10 units to get erect. So I'm now thinking of buying new trimix from the previous pharmacy.

Absolutely yes. I looked at the labels from two different pharmacies and the amount of the three medications were wildly different. "Trimix" is more a technique ('mix these three medications'), than a recipe. Every pharmacy is different, though there are often similarities in their "recipes".

Always re-titrate when you change pharmacies. Also whenever you get a new vial, back off the dose on that first shot. There is often not perfect quality control and one vial might be stronger or weaker than the last one.

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[GoodWood]

What is your Trimix prescription? List it here please so we know what you are talking about. How much prostaglandin? How much Papaverine? How much phentolamine?

[CanGetItUpButNotOff]

What is your Trimix prescription? List it here please so we know what you are talking about. How much prostaglandin? How much Papaverine? How much phentolamine?

+1

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[ElbowRoom]

Compounded drugs are kind of a gray area with the FDA. They are not as tightly regulated as mass-produced prescription drugs. In *theory* if you get two batches with the same proportions of medications in them, say both 30mg PAP/1mg Phen/10mcg PGE (my current vial)...then they should act the same.

BUT. I had a pharmacy that was terrible on consistency, one vial was great and the next gave no effect at all. I took the bad vial back to them and they replaced it and all was well. But awful that they couldn't get it consistent. I fired them and got a different pharmacy which has been really good and consistent.

This is why I say you need to back off your first dose whenever you get a new vial. If they get it wrong and it's overly strong, you'll land in the ER. My normal dose is 0.14ml to 0.17ml. When I get a new vial my first shot is 0.10-0.12ml to make sure it works as intended.

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