Reverse Titration

Sticking a needle Where? Courage, guidance and help.
still_crazy
Posts: 74
Joined: Sat May 06, 2023 10:05 am
Location: FL

Reverse Titration

Postby still_crazy » Tue Mar 26, 2024 3:13 pm

I've been injecting for about 10 months now. In the beginning I did the typical titration process where I started with 5 units of Trimix (30Pap-1Phen-25Pge) and worked my way up (+5 each time). I ended up using about 24-26 units. This gave a great erection that lasted a little over 2 hours, but was quite achey.

Recently I've been experimenting with Titrating back to a lower dose. I've worked my way down to about 18 units and still get good results with less ache. I am using a ring for about the first 10 minutes and make sure that I work the Trimix in very well with lots of massaging (squeezing up and down the penis for a couple of minutes). I still get a good 2 hour erection. I will keep dropping the dose by 2 units each time until it's not enough to do the job.

I believe that in the past I wasn't massaging the mix in well enough (thus requiring a higher dose), and the ring does really seem to help. These were both tips from you guys on the forum. Thanks.

Anyone else here find that they were able to back off on the dose and still get good results as long as proper technique is used?
Age 66. RALP Jan-2023. Non-nerve sparing.
VED exercise most days, Trimix T-106 (30-1-25), ~20 units.
Bending trauma around age 50, resulting in mild Peyronies.

sogwap
Posts: 445
Joined: Wed Jul 20, 2011 8:10 am
Location: Ontario, Canada

Re: Reverse Titration

Postby sogwap » Tue Mar 26, 2024 10:56 pm

My starting dose was 10 units. I then worked my way up to 20 units.
Since then I've reduced back down to 10 units.
My urologist wanted me to do even less. But my wife gets upset when things don't work.
Age: 68. Struggled with ED/PE for years.
Used Viagra for 10+ years with mixed success.
In May 2022 started using Trimix with very good results.
Feb 2023 developed PD
2023 still in treatment for PD, and still using Trimix with very good results

Martin6469
Posts: 565
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Reverse Titration

Postby Martin6469 » Thu Jul 25, 2024 12:28 pm

I've injected Trimix for seven years with great results. The amount I needed dropped steadily for several years for some strange reason, bottoming out at 70% of the initial amount, but in the last ten months or so I've needed slightly more each month or so. I "calibrate" the dose by shooting for a two-hour erection.
Last edited by Martin6469 on Thu Jul 25, 2024 3:55 pm, edited 1 time in total.
Age 79 in 2024. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.

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bldoink
Posts: 3829
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Reverse Titration

Postby bldoink » Thu Jul 25, 2024 12:45 pm

Yes, I inject less than I did initially did. I believe that initially it was due to improving my injection technique and getting accustomed to the drug. I reduced further when I added a novelty/sex shop cock ring to the mix. I stack with sildenafil sometimes which also allows a lower injection dose.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Not nerve sparing. C in margins. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ 8 - 14 units. Originally Edex20, then compounded PGE due to cost. Inject. 12 yrs. It works. Treasure coast of FL.

RJ_in_Pa
Posts: 103
Joined: Tue Oct 17, 2023 4:34 pm
Location: Pa

Re: Reverse Titration

Postby RJ_in_Pa » Mon Jul 29, 2024 8:06 pm

I was just looking for this thread a couple weeks ago and couldn’t find it.

I got my second vial of Trimix and went right back to injecting 18 units. The first use I had the usual good results, but had an erection for over 3 hours. Having a “one and done” wife (which is better than a ‘none and done’ wife), I have to find things to do while I wait for it to go down. A couple times, I was able to pleasure myself to a second (solo) orgasm, but it takes a lot work to get there. This is probably because I had an RP, not sure, but if I get there, it is a pretty powerful orgasm.

Anyhow, I decided to try reducing the units and see if it affects the quality of my performance. I’ve been dropping 2 units at a time. I’m down to 10 units and still have an erection for 2 hours after sex. No complaints from the wife either, so I’m going to try 8 units and see what happens.

On a similar note, it’s been 11 months since my RP. My Uro said it could take 9 to 24 months for the nerves to awaken so that I could get a natural erection. I am able to get maybe 75 % erect now without drugs or VED with just playing with it, almost erect enough to try penetration. I was wondering if this is a good sign? Could this be why I’m able to reduce the number units and still get strong and lasting erections?

Or maybe just wishful thinking?

Rj
64, Radical Prostatectomy in 2023, pills did nothing. Currently on Trimix with great success.

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bldoink
Posts: 3829
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Reverse Titration

Postby bldoink » Mon Jul 29, 2024 10:50 pm

RJ_in_Pa wrote:... I was wondering if this is a good sign? Could this be why I’m able to reduce the number units and still get strong and lasting erections?

Or maybe just wishful thinking?

Rj

For sure a good sign.
Could be.
A little wishful thinking can be good so why not.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Not nerve sparing. C in margins. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ 8 - 14 units. Originally Edex20, then compounded PGE due to cost. Inject. 12 yrs. It works. Treasure coast of FL.

RJ_in_Pa
Posts: 103
Joined: Tue Oct 17, 2023 4:34 pm
Location: Pa

Re: Reverse Titration

Postby RJ_in_Pa » Fri Aug 02, 2024 3:37 pm

After my last post, we attempted 8 units. Went great. Wifey satisfied. 1 1/2 hour post sex erection.

That was 2 days ago. Today, the wife had plans for a few hours this afternoon and I was hoping to have a go at it before she took her shower, but she said she didn’t have enough time.

After she left the house, I proceeded to try to get a natural erection. Same results. I get very chubby, but just can’t get him to stand at attention.

Wondering just how many units it would take to get an erection, I decided to do a test. I injected just 2 units and was erect in the same amount of time as I was with the higher units. I proceeded to pleasure myself, doing some edging and some nice slow teasing strokes, and when I finally let it finish, it was one of the strongest solo orgasms I’ve had post RP.

Unlike with higher doses of trimix, my erection went done almost immediately, kinda like it used to before my RP. I did remain chubby for about 45 minutes.

What kinda surprises me is even at the highest dose (20mg), Cialis does nothing for me.

I don’t know of what value this might have to anyone else, but I had to tell someone! :-)

Still_crazy-please check your PMs.
64, Radical Prostatectomy in 2023, pills did nothing. Currently on Trimix with great success.

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bldoink
Posts: 3829
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Reverse Titration

Postby bldoink » Sat Aug 03, 2024 12:50 pm

RJ_in_Pa wrote:...I don’t know of what value this might have to anyone else, but I had to tell someone! :-)...

It's always nice to hears about successes.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Not nerve sparing. C in margins. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ 8 - 14 units. Originally Edex20, then compounded PGE due to cost. Inject. 12 yrs. It works. Treasure coast of FL.

ejefowe
Posts: 48
Joined: Sun Feb 25, 2024 9:16 am

Re: Reverse Titration

Postby ejefowe » Sat Aug 03, 2024 6:12 pm

I am 100% NO natural erections. Alprostadil causes aches so I've started using Trimix. Same ache tho not as bad. We introduced Lidocaine to the mix....MUCH better results. No one is the same.... you have to advocate for yourself and demand to try different things!!!

still_crazy
Posts: 74
Joined: Sat May 06, 2023 10:05 am
Location: FL

Re: Reverse Titration

Postby still_crazy » Mon Aug 12, 2024 8:36 am

I have moved from a 30-1-25 trimix to a 30-1-10 (where 25 and 10 are PGE mcg) I seem to get the same erection with the same dose and have very little ache... so this is a welcome change for me. I'm currently using about 20 units. Will try to go lower. I find that at least 2 minutes of good massaging (squeezing up and down the shaft) really helps evenly distribute the trimix to provide a much better erection. (Thanks to others on this site who suggested that!)

@RJ_in_PA Glad to hear sounds of success!
My wife and I don't have sex very often (2 or 3 times a month). From some research that I've read, it seems that getting arterial blood flow into the penis at least a couple times a week is a good thing (to replace nocturnal erections that I no longer have). I'm gonna try to find time for a smaller dose injection that will produce at least a semi woody at least a couple times a week. I still try to use the VED at least every other day as well (but this is just veinous blood into the penis, from what I understand). Of course, our whole life doesn't revolve around our penis, but we do what we must! ;)
Age 66. RALP Jan-2023. Non-nerve sparing.
VED exercise most days, Trimix T-106 (30-1-25), ~20 units.
Bending trauma around age 50, resulting in mild Peyronies.


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