Alprostadil Frustration

Sticking a needle Where? Courage, guidance and help.
RJFour
Posts: 1
Joined: Thu Oct 26, 2023 9:28 pm

Alprostadil Frustration

Postby RJFour » Tue Nov 14, 2023 10:22 pm

Prostaglandin E1

U-100 Syringes 1/2" .3

About six months ago, I had a test injection at 35 units at the Uro when I had the Venous leak checked. That all checked out, however the erection was almost four hours and had to be injected twice with Phenylephrine to bring it down. A month later, I had another injection at the Uro to test a starting dose. I injected 25 Units and again, it was almost four hours long and had to receive another Phenylephrine injection to bring it down. The third time, we did 10 units, and this resulted in an erection of 5 minutes and was instructed to try 15 units at home as a starting dose.

I've done about 15 injections so far and I can't tell if I'm injecting wrong, medication is going bad (not shaking enough?), syringes are too long but the erections are not consistent.

If I inject 12 units, it work for about 20 minutes with some work.

If I inject 14 units, it works about 3 hours.

I also think I have better results injecting on the left rather than the right side. Also the erections are okay, not perfect, so I'm not sure why there is a huge disparity when the doses are small.

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bldoink
Posts: 3719
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Alprostadil Frustration

Postby bldoink » Tue Nov 14, 2023 11:01 pm

It seems strange that it would vary that much. Your injection technique may still need a little improvement. Read as many of the injection threads as you can stand.

At the moment I see two options. Either enjoy the 3 hours or go for the shorter version but add a novelty/sex shop cock ring. You'll have to experiment to find what rings work best for you. Expect rejects.
R.R.P 2011 Mayo Jacksonville, Dr. M. Wehle. Nerve sparing - damaged. C in margin. Radiation 2023, V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 12 yrs. It works. Treasure coast of FL.

Martin6469
Posts: 501
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Alprostadil Frustration

Postby Martin6469 » Thu Nov 16, 2023 2:01 pm

I have small corpora, so I use 5/16 in. (8mm) needles. You're in a corpus if there's no more resistance to plunger travel than if the needle were in air, and there should be no pain from the fluid flow out of the needle. After injecting, immediately squeeze your shaft 6-8 times; the corpora have fluid connections and this pumps some Alprostadil into the other corpus, to produce a straight-ahead erection.
Age 78 in 2023. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.

sogwap
Posts: 398
Joined: Wed Jul 20, 2011 8:10 am
Location: Ontario, Canada

Re: Alprostadil Frustration

Postby sogwap » Thu Nov 16, 2023 4:47 pm

Does "All checked out" mean you have or don't have a venous leak?

I'm no doctor but pretty sure the typical starting dosage is 10-20 units.

As bldoink said try cock ring.

Also, lots of guys keep a log of their injections.
I note the following:

date of injection,
amount injected,
location of injection (left side right side etc),
erection hardness,
length of time erection last,
plus any notable notes.

Notes would include anything. For example:
A couple of times it took 20-30 minutes to start working. Other times I'm erect in 5 minutes. Such notes help figure out why.
Things that brought the erection down. I used to lay awake for hours waiting for the erection to go away, now either get up, which makes it go down I go to sleep since I've never been fully hard for more than 3.5 hours.
I also have notes regarding my partner's reaction with the aim to be a better lover.
Age: 68. Struggled with ED/PE for years.
Used Viagra for 10+ years with mixed success.
In May 2022 started using Trimix with very good results.
Feb 2023 developed PD


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