Trimix-freeze or not to freeze

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Otter46
Posts: 62
Joined: Fri Sep 01, 2017 11:50 am
Location: Michigan

Trimix-freeze or not to freeze

Postby Otter46 » Sat Apr 22, 2023 5:25 pm

Hi guys,

So I’ve read on FT where some guys freeze their Trimix & some just leave it in the fridge. I’ve filled 4-5 syringes when I get a new order & then freeze vial & syringes. And when those r gone, I take the vial out of the fridge, thaw it out & fill some more. What’s the verdict, freeze it or not?
So far seems to work ok, I get a rock hard hardon when I inject, but I will say I’m on 5mg Cialis which I take @ nite & when I’m contemplating sex the next day, I also take a 20mg Cialis along w it. So whether I’m getting hard because of the Trimix or the combo of both that & the Cialis.
Thanks much for anyones two cents.

Dave (Otter46)
78yo., married 54 yrs. Started Bimix injections in August ‘21, PA just switched me over to Trimix 5-22. 31 Gauge/5/16” needle. ED drugs not working that well anymore.
Thankful for this board & the guys that use it.

sogwap
Posts: 393
Joined: Wed Jul 20, 2011 8:10 am
Location: Ontario, Canada

Re: Trimix-freeze or not to freeze

Postby sogwap » Sat Apr 22, 2023 8:51 pm

I asked my urologist about this, He said there is no need to freeze Trimix and it will keep for a year in the refrigerator. As long as the medicine is clear it should be good.

I just read a report today about someone who used 2.5 year old bottle of Trimix kept in the refrigerator and said it worked as well as from a new bottle.
Age: 68. Struggled with ED/PE for years.
Used Viagra for 10+ years with mixed success.
In May 2022 started using Trimix with very good results.
Feb 2023 developed PD

nitejazz
Posts: 11
Joined: Tue Feb 22, 2022 7:15 pm

Re: Trimix-freeze or not to freeze

Postby nitejazz » Sun Apr 23, 2023 1:25 pm

I freeze my trimix. Generally draw up 10 or 15 syringes and freeze them also and thaw out each dose as necessary. It only takes about 5 minutes to thaw completely in the syringe so its not a problem. I found one that was at least 2 1/2 years old a couple of weeks ago and it worked as well as fresh. I knew it was at least that old as I have changed strength since then and it was at the old size. Before I started freezing I noticed a decline in effect after 4 months in the friddge. YMMV
74, married 44 years, ED for about 18 months tried pills not much effect with bad headaches, tried VED not happy, finally found trimix with the suggestion of cardiologist 8-) still experimenting with dose but happier.

bencavill974
Posts: 5
Joined: Mon Mar 28, 2022 12:07 pm

Re: Trimix-freeze or not to freeze

Postby bencavill974 » Sun Apr 23, 2023 1:51 pm

Lastly, everything will be fine.

ape1100
Posts: 201
Joined: Wed Feb 23, 2022 12:35 pm

Re: Trimix-freeze or not to freeze

Postby ape1100 » Sun Apr 23, 2023 2:27 pm

I froze 3 of four vials and one in the fridge. The one in the fridge started dropping efficacy after a couple of months where i needed to up the dose in order to get the same effect. That does not happen with the frozen ones. I dont use much which is why I keep it frozen. Currently I’m on vial 3 of 4 that i got in February of 2022. Kept frozen I still only need the original 5 units which lasts over 3 hours. Thats my experience.
50+ yrs old. married 25+ years. hypothyroid, on TRT. 10+ years ED, viagra, cialis now 50% ineffective. now on trimix 2MG phentolamine/30MG papaverine/20MCG alprostadil

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bldoink
Posts: 3683
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Trimix-freeze or not to freeze

Postby bldoink » Sun Apr 23, 2023 2:48 pm

It's the alprostadil that loses potency quickly when not frozen. If your tri-mix isn't really alprostadil dependent then alprostadil degradation won't really be noticed much if at all. I suspect that in a mix heavy with alprostadil you will notice degradation fairly rapidly.

Keep in mind I'm not a medical or pharmacological expert of any kind. I did not sleep in a Holiday Inn Express last night.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.

azmike
Posts: 145
Joined: Thu May 05, 2022 12:27 pm

Re: Trimix-freeze or not to freeze

Postby azmike » Sun Apr 23, 2023 4:15 pm

I make up several syringes and freeze them. I also freeze the bottle. No issues.

Frenchie
Posts: 165
Joined: Sun Sep 11, 2022 11:14 am

Re: Trimix-freeze or not to freeze

Postby Frenchie » Sun Apr 23, 2023 4:42 pm

bldoink wrote:It's the alprostadil that loses potency quickly when not frozen. If your tri-mix isn't really alprostadil dependent then alprostadil degradation won't really be noticed much if at all. I suspect that in a mix heavy with alprostadil you will notice degradation fairly rapidly.

Keep in mind I'm not a medical or pharmacological expert of any kind. I did not sleep in a Holiday Inn Express last night.

So Alprostadil should always be kept in the freezer and not the fridge?
How many hours can Alprostadil survive in room temperature if I wanna hook up with some girl and have a prefilled syringe with me? Does it lose efficacy in 2-3 hours or longer?
Venous like since I was 20 years old. Pills don't work too well. Thinking of implant in the future

Otter46
Posts: 62
Joined: Fri Sep 01, 2017 11:50 am
Location: Michigan

Re: Trimix-freeze or not to freeze

Postby Otter46 » Sun Apr 23, 2023 6:20 pm

Thanks guys for all of ur replies, as always appreciate all of ur input. I’ll check w my URO on Tuesday to get his take on freezing Trimix. Appreciate all of u guys & the help that u r all so willing to help.

Dave (Otter46)
78yo., married 54 yrs. Started Bimix injections in August ‘21, PA just switched me over to Trimix 5-22. 31 Gauge/5/16” needle. ED drugs not working that well anymore.
Thankful for this board & the guys that use it.

User avatar
bldoink
Posts: 3683
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Trimix-freeze or not to freeze

Postby bldoink » Sun Apr 23, 2023 7:42 pm

Frenchie wrote: So Alprostadil should always be kept in the freezer and not the fridge?
How many hours can Alprostadil survive in room temperature if I wanna hook up with some girl and have a prefilled syringe with me? Does it lose efficacy in 2-3 hours or longer?

I think you'll be fine. As for how many times it can be carried on a date night that doesn't result in it's use, with refrigeration in between date nights, well that would be the real question. And I don't have that answer.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.


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