Is this the end of trimix?

Sticking a needle Where? Courage, guidance and help.
seekonk
Posts: 10
Joined: Thu Jul 22, 2021 10:33 am

Is this the end of trimix?

Postby seekonk » Sun May 08, 2022 5:57 pm

First post here.

I’m 54, fit and in great shape. Until 3 years ago I could still have marathon sex for 4 hours on levitra, but I started losing my erection for no reason in the middle of enjoying myself. No amount of psychobabble solved that for me.

I started injections. After 2 years of injections I went from achieving rock hard 3-4 hour erections from a low dose of alprostadil to disappointing erections on large doses of a concentrated quadmix. This deterioration happened relatively fast, over the course of 2-3 months. I can get it hard but within just a few minutes the base, which used to be rigid and unbendable coming out of my body, starts getting floppy and then it’s all downhill unless I do an extra-large second injection on the other side, sometimes a third over the course of 45 minutes or so.

A sleepover with night and morning sex could easily cost me 4-6 injections this way and still be unsatisfying, not to mention sore and pretty much useless for two weeks after.

I stopped dating and took a half year break from sex and injections (and therefore from getting off at all, since pills do nothing for me now so I can’t jerk off without injecting). I hoped things would come back, but the break didn’t help. It’s still the same, where I can keep hard by injecting more and more, which isn’t sustainable.

Has anybody come back from escalating injection doses? If so how? I’m pretty sure there is some injury or scarring and wonder if anybody has had that problem successfully treated.

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SteveSW
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Joined: Sat Sep 08, 2018 6:23 pm
Location: St. Louis, MO

Re: Is this the end of trimix?

Postby SteveSW » Sun May 08, 2022 6:17 pm

What strength and dosage were you injecting? When I gave up on it, or rather it gave up on me I was injecting 70 units of 30/6/100 Trimix. Even that started to fail me. Your question can only be answered knowing your strength, and dosage. I don't know of any man who had Trimix fail and then come back to it and have it work.
20 years of severe Peyronie's plaque, 90 curve, hinging and ED. Cost me 1.5" L and 1" G.
Implanted 2/18/21, AMS CX, 18 CM + 3 RTE, penoscrotal. Have gained 3/4". Gay, age 68.

seekonk
Posts: 10
Joined: Thu Jul 22, 2021 10:33 am

Re: Is this the end of trimix?

Postby seekonk » Sun May 08, 2022 6:58 pm

Quadmix 25 units of 30/3/20/0.2 gets me 95 percent hard over the course of 10 minutes but then immediately it starts getting floppy again at the base and standing up or penetration will push the blood out. Larger doses don’t help more. A second or 3rd injection will give a little more duration. I was on an even higher 30/3/100/0.2 before this but it didn’t work better and the high alprostadil component caused pain that was counterproductive.

Two years ago just 5 units of the starter trimix, much weaker than this, kept me hard for 4 hours. I got that lock-in feeling where the blood was completely trapped. It pointed up and wouldn’t bend at the base. I could hang towels from it if I wanted to. It would last longer than I wanted it to if I went over 5 units and I sometimes had to do compressions and showers to make it go down. Now, no matter what, the blood just seems to start draining away right away.

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bldoink
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Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Is this the end of trimix?

Postby bldoink » Sun May 08, 2022 7:26 pm

Adding novelty/sex shop cock rings to the mix might get you a little more time but unfortunately it sounds like your injection run is going to be very limited. It sounds like you're going to be left with a VED and constriction rings or an implant. Sorry.

Good luck.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.

Martin6469
Posts: 227
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Is this the end of trimix?

Postby Martin6469 » Fri May 13, 2022 11:34 pm

Ask a urologist about venous leaks. I don't have this but it's talked about a lot on FT.
Age 76 in 2021. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.

seekonk
Posts: 10
Joined: Thu Jul 22, 2021 10:33 am

Re: Is this the end of trimix?

Postby seekonk » Tue May 17, 2022 4:29 pm

Thank you, yes, I think it is pretty clear that I have developed venous leak, probably from scarring or fibrosis. From all I have read there is no proven treatment for venous leak besides implant, but I’m seeing a urologist soon and will discuss.

crazyjoe
Posts: 192
Joined: Thu Feb 18, 2021 4:22 pm

Re: Is this the end of trimix?

Postby crazyjoe » Tue May 24, 2022 11:57 am

I feel really bad for you and all other guys who lose sensitivity to injections. They are so wonderful for varying amounts of time depending on the individual -- mine was 8 months of escalation up to 150 PGE in Quadmix. Then I starting losing effectiveness in erections from them and developed a loss of length and a downward curve. I had no choice then but to get an implant.

In the surgeon's notes it said I was obliterated with scarring making the implant surgery difficult -- I was under for 2.5 hours.

Now, 3 months out, I have regained most of my lost length, thanks to VED and the Perito exercise.

Just my story -- on the other hand, I have always envied BDloink's experience of 10 years injection effectiveness using straight PGE. Seems the Papervine in Trimix is the culprit. That's what my surgeon told me -- he said that the only guys he's operated on that didn't have some scarring or fibrosis from injections had been using straight PGE.
75, used pills, injections -- all lost effectiveness. Titan implanted by Eid in Feb '22.

slipnslider
Posts: 173
Joined: Tue Jun 09, 2020 4:22 pm

Re: Is this the end of trimix?

Postby slipnslider » Wed May 25, 2022 1:44 pm

seekonk wrote:First post here.

I’m 54, fit and in great shape. Until 3 years ago I could still have marathon sex for 4 hours on levitra, but I started losing my erection for no reason in the middle of enjoying myself. No amount of psychobabble solved that for me.

I started injections. After 2 years of injections I went from achieving rock hard 3-4 hour erections from a low dose of alprostadil to disappointing erections on large doses of a concentrated quadmix. This deterioration happened relatively fast, over the course of 2-3 months. I can get it hard but within just a few minutes the base, which used to be rigid and unbendable coming out of my body, starts getting floppy and then it’s all downhill unless I do an extra-large second injection on the other side, sometimes a third over the course of 45 minutes or so.

A sleepover with night and morning sex could easily cost me 4-6 injections this way and still be unsatisfying, not to mention sore and pretty much useless for two weeks after.

I stopped dating and took a half year break from sex and injections (and therefore from getting off at all, since pills do nothing for me now so I can’t jerk off without injecting). I hoped things would come back, but the break didn’t help. It’s still the same, where I can keep hard by injecting more and more, which isn’t sustainable.

Has anybody come back from escalating injection doses? If so how? I’m pretty sure there is some injury or scarring and wonder if anybody has had that problem successfully treated.


I think your story is a common one for guys with venous leaks, or other ED causes that get worse over time. My ED is caused by a loss of sensation due to adult circumcision, or possibly hormonal damage from propecia. After 2 years of trimix usage, I've only had to go go from 5 units up to about 7, with a moderate strength mix.

My main concern is scarring, as there are now times when I stick the needle in and can't push the plunger down, which I think means its stuck in some scar tissue.
44, ED problems began around age 28 when I was on finasteride for hair loss, and also got circumcised so I lost a lot of sensation. Pills gave me bad headaches and other side effects. Now using trimix 30/1/20. So far so good.

ape1100
Posts: 46
Joined: Wed Feb 23, 2022 12:35 pm

Re: Is this the end of trimix?

Postby ape1100 » Wed May 25, 2022 1:53 pm

My main concern is scarring, as there are now times when I stick the needle in and can't push the plunger down, which I think means its stuck in some scar tissue.[/quote]

i have had a hard time pushing the plunger sometimes but i think its the needle not making its way into the right spot. i just pull out, try again, push a little deeper and success. from reading on here, i have even started to aspirating blood into the needle just to know im in the right spot. has been working really good. just my experience.
50+ yrs old. married 25+ years. hypothyroid, on TRT. 10+ years ED, viagra, cialis now 50% ineffective. now on trimix 2MG phentolamine/30MG papaverine/20MCG alprostadil

vinnylid
Posts: 64
Joined: Sat Sep 17, 2016 9:33 am

Re: Is this the end of trimix?

Postby vinnylid » Wed May 25, 2022 4:42 pm

I inject about an inch back from the glan. I take half a viagra 1 hour before injecting which help get a bigger target. Most of my scar tissue was already present before starting trimix. Trying to have sex without an adequate erection damages the penis
77 years old; Viagra, herbals and stimulants have all stopped working. Treating psoriatic arthritis and thyroid. Low testosterone-started HRT april 2018; using Quadmix 20 units,Xailla cockring, Lafayette, Georgia usa


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