Freezing TriMix vials

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sommers
Posts: 21
Joined: Thu Sep 26, 2019 3:37 am
Location: St Louis

Freezing TriMix vials

Postby sommers » Tue Apr 21, 2020 2:02 pm

I'm reading that vials can be frozen to prolong life. Is there any danger in the vial exploding (I assume they're glass) like a glass bottle of coke will (expansion of the liquid)
I know I have put a bottle in the freezer to quick cool it only to forget I did it and find out the next day it had exploded in the freezer
thanks for any and all replies!

graymare
Posts: 96
Joined: Thu Feb 19, 2015 3:50 pm

Re: Freezing TriMix vials

Postby graymare » Tue Apr 21, 2020 2:06 pm

My vials are not full enough to break from expansion, and they are made of fairly thick glass. They've been frozen a long time with no issues.
Married, 66 yrs old, ED for 22 yrs. On TriMix for 5 yrs. Live in the Adirondacks of NY. Would be a nudist if it weren't for the black flies and the short summers. :D

dtwarren1942
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Joined: Wed Oct 27, 2010 7:58 pm
Location: Jersey Shore

Re: Freezing TriMix vials

Postby dtwarren1942 » Tue Apr 21, 2020 4:23 pm

When I was using Trimix, it would be shipped 5 vials frozen in a dry ice shipping container with instructions to keep frozen until needed for use.
Age 78
Diabetic
Pumping
Started Trimix injections 8/'11

Agfa13
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Joined: Thu Oct 31, 2019 6:03 pm
Location: Laurel, Maryland

Re: Freezing TriMix vials

Postby Agfa13 » Tue Apr 21, 2020 8:38 pm

I used to use Bimix. I would have a monthly vial come in, freeze it, and use it down the road. Out of about 17 vials, only one was bad. By that, when I defrosted the vial, it looked like shattered glass debris was floating inside.

544kenmatt
Posts: 146
Joined: Sun Nov 17, 2019 10:17 am
Location: ROCHESTER , NY

Re: Freezing TriMix vials

Postby 544kenmatt » Wed Apr 22, 2020 8:53 am

it should not do that. Call the pharmacy and see if they will replace it.
I have an implant now, but when I used trimix, i would draw all of my doses up into syringes (0.4ml) and freeze them. I would pull one out as needed and it would defrost in five minutes or so if i rolled it between my palms.
AMS 700 LGX 10/31/2019. age 63

once a writer
Posts: 237
Joined: Tue Jan 07, 2014 5:53 pm
Location: Oregon

Re: Freezing TriMix vials

Postby once a writer » Wed Apr 22, 2020 11:20 am

when I defrosted the vial, it looked like shattered glass debris was floating inside


Any possibility that what you saw was crystallized medication? Some guys here on FT have reported that their stuff crystallized after freezing, and apparently some pharmacists warn of that possibility.
Eugene, Oregon, USA. Born 1941. Married 1968. ED since mid-1990s. Began trimix January 2014. Dosage gradually increased over time. Added cock ring in 2016. After dosage reached 30 units, switched to quad mix in May 2018. On blood pressure meds.

Old Guy
Posts: 196
Joined: Tue Mar 31, 2020 4:31 pm
Location: Ohio

Re: Freezing TriMix vials

Postby Old Guy » Wed Apr 22, 2020 1:25 pm

When I used Trimix and Quadmix it was shipped overnight in a Styrofoam box with ice packs. 3 vials would go into the freezer minutes after delivery, one vial left in fridge. I found after 5-6 weeks the one in the fridge would start to lose potency. When I left one Trimix in the freezer for 4 months and defrosted it, the potency was not what it should have been. A tech told me there is one ingredient in Trimix that will lose it's potency within hours if not refrigerated, and refrigeration only slows it down. Freezing slows it down a bit more.
Never had an issue with any vials breaking though.
68 years old when Coloplast Titan OTR implanted 11-08-2019. Viagra, Trimix, QuadMix all failed after a while. Married to my beautiful 17 year younger wife for 32+ years. As much as it was a tough recovery for me I'm glad I had it done.

djones36117
Posts: 14
Joined: Wed May 29, 2019 3:34 pm

Freezing TriMix vials

Postby djones36117 » Thu Apr 23, 2020 10:56 am

why do some of you feel it is necessary to post a dick pic or have it as your profile pic, damn.

bldoink
Posts: 1860
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Freezing TriMix vials

Postby bldoink » Thu Apr 23, 2020 1:37 pm

djones36117 wrote:why do some of you feel it is necessary to post a dick pic or have it as your profile pic, damn.

My thoughts also. However, the site administrator seems to approve.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 12 units. Originally Edex20, then compounded PGE-1 - cost. Inject. ~ 8 yrs. It works. Treasure coast of FL.

User avatar
ShouldIwait
Posts: 12
Joined: Fri Apr 03, 2020 12:36 am
Location: So Calif

Re: Freezing TriMix vials

Postby ShouldIwait » Thu Apr 23, 2020 3:16 pm

Only tri needs to be frozen/refrigerated as it is the Alprostadil that degrades.
BiMix travels quite well at room temperature--but Tri/Quad works better for most men...


-----------------

Bimix
Papavarine
Phentolamine

Trimix
Alprostadil / prostaglandin
Papaverine
Phentolamine

-------------------
Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction.

Abstract
A three-drug injection mixture of alprostadil 12.5 microgram/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for stability at 23 deg C, 4 deg C, -20 deg C and -70 deg C. The injection remained clear and colorless in all samples throughout the study. Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. Alprostadil was the least stable of the drug components at room temperature and under refrigeration. About 8% alprostadil loss occurred in five days at room temperature; under refrigeration losses of about 6% and 11% occurred after 1 and 2 months, respectively. Frozen at -20 deg C and -70 deg C, less than 5% loss of any of the drug componenets occurred in 6 months. A beyond-use date of 6 months when stored frozen at -20 deg C and 1 month when stored refrigerated at 4 deg C is appropriate for batches of the injection that have passed sterility testing. Room temperature exposure should be limited, and the vial should be returned to refrigeration as soon as possible.
ED 10-12 years. Pills stopped working now on Quad Mix. Considering implant :?


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