Trimix efficacy over time

Sticking a needle Where? Courage, guidance and help.
c0r5a38
Posts: 10
Joined: Tue Nov 15, 2016 8:36 pm

Trimix efficacy over time

Postby c0r5a38 » Sun Dec 30, 2018 11:54 am

Hello. I've started on Trimix (auto-inject) 2+ years ago with good results, compound is 30/1/0.01, dosage crept up over time from 5-6 units to 10 all under doc's/np guidance. Over the last five weeks results have been less than satisfactory, barely firm enough for intercourse (call it a 6-7 out of 10). I thought perhaps the Trimix aged (7 months) so i refilled but no change. Is this to be expected? Does our body adjust to the med and we require an increased dosage over time? Or should the mix be modified?
Prostatectomy in Feb 2016, 65 years, 20 lbs. overweight, controlled hbp. Perhaps TMI? :)

Thanks!
Diagnosed May 2012 with prostate cancer, 3.3 Gleason, active surveillance until February 2016 when biopsy result was Gleason 3.4. Radical prostatectomy performed by Dr. Peter Scardino at Sloane. Under Dr. Mulhill's care at Sloane for sexual health.

QuestionGuy
Posts: 103
Joined: Tue Sep 22, 2015 6:50 pm

Re: Trimix efficacy over time

Postby QuestionGuy » Sun Dec 30, 2018 1:28 pm

I've seen alot of posts from men who were using TRI-MIX for years and never developing a tolerance or degraded results....but that was not my experience. I started on the weakest BI-MIX 3 years ago and got 5 hour erections; I'm now using the strongest TRI-MIX and QUAD-MIX available for 30 minute partial erections where if we both lay on our side, I can "scrunch it in". When I started injecting it was like getting a new lease on life, but i did seem to developed a tolerance. I've tried abstaining for a while, to see if I can get the old better results back.....but to no avail . I'm looking at implants now and was surprised to find many on this forum who once injected, actually prefer life with the implant. I personally did not mind excusing myself to inject, as it seemed much less uncomfortable than the humiliation of ED. I'm hesitating on the implant because its a point of no return....i would love to hear what others think.
I'm 55. PostFinasterideSyndrome/Peyronies . Initially had good erections but numbness. Now erections are compromised, but good sensitivity. I see Dr. Irwin Goldstein and do : TRIMIX-Clomiphene-Arimidex –Cabergoline -Cialis -Traction-VED-Pshot-gainswave

FMLFML85
Posts: 93
Joined: Thu May 10, 2018 12:18 am

Re: Trimix efficacy over time

Postby FMLFML85 » Sun Dec 30, 2018 2:25 pm

@ questionguy
things that make me hesitate: Insurance refusing to help pay, surgical complications which could result in removal of implant, loss of length (one guy here said he went from a 8" to a 6"), Skinny flat boners where the corpus spongiosum (bottom of shaft) dosn't inflate as well as the glans/head not inflating, loss of sense of a sextual response, not being able to cum.

How long of breaks did you take? Did you still masturbate/sex? Did you take viagra during your breaks? Do you ever have a random good day where the trimix works better? Do you have any natural ability to get a erection what so ever?
33 years old, devorced. ED from abusing a penis pump. Pills having little effect, starting carverject theropudically june 13th

dtwarren1942
Posts: 1575
Joined: Wed Oct 27, 2010 7:58 pm
Location: Jersey Shore

Re: Trimix efficacy over time

Postby dtwarren1942 » Sun Dec 30, 2018 5:14 pm

My Trimix worked well for about three years and then I had to increase its strength every six months until 75 units no longer provided satisfactory results. Not sure whether the loss of effectiveness was a result of developing tolerance or if the cause (Diabetes/veneous leak) of my ED worsened.
Age 77
Diabetic
Pumping
Started Trimix injections 8/'11

User avatar
Larry10625
Posts: 4704
Joined: Sat Apr 15, 2017 10:56 am
Location: Ontario, CANADA

Re: Trimix efficacy over time

Postby Larry10625 » Sun Dec 30, 2018 5:20 pm

dtwarren1942 wrote:My Trimix worked well for about three years and then I had to increase its strength every six months until 75 units no longer provided satisfactory results. Not sure whether the loss of effectiveness was a result of developing tolerance or if the cause (Diabetes/veneous leak) of my ED worsened.



Probably both. :(

Larry
51 years old, married 29 years. Implanted Mar 30/17 by Dr. Brock of London, Ont, CANADA. (AMS 700 LGX 18 + 2). Had implant removed Apr 29/17 due to Septic Shock. Liposuction By Dr. Gan and re-implant by Dr. Brock (AMS LGX 15 + 2) Dec 14/17.

bldoink
Posts: 1313
Joined: Mon Apr 03, 2017 12:58 am
Location: Fl.

Re: Trimix efficacy over time

Postby bldoink » Sun Dec 30, 2018 9:01 pm

I'm not a medical professional of any kind. Anything I post is based on my own experiences at best and hallucinations or delusions at worst. Nothing I post should be misconstrues as medical advice. Always ask your doctor and follow his/her advice.

I don't know if your basic cause of ED is changing or worsening or if you're building tolerance.

The volume of meds you're injecting is pretty low by comparison to most users. So you may have a good ways to go toward increasing volume.
If I understand your formula correctly your alprostadil (PGE1) component is low. So you may have a good ways to go toward increasing the strength of your mix.

I added novelty (sex shop) cock rings to the mix. It helps some guys, me included. If you haven't tried that option you might want to consider it. I've given my take on it several times. If interested you'll have to experiment to find what works. You want tight enough to assist without necessitating time limits on use.
R.R.P 2011 Mayo Jacksonville by Dr. Michael Wehle. Nerve sparing - damaged. V.E.D, Viagra and Alprostadil (80mcg/ml) injections @ ~ 12 units. Originally Edex20. Switched to compounded Alprostadil - cost. Injecting ~ 8 yrs. It works. Treasure coast of FL.

c0r5a38
Posts: 10
Joined: Tue Nov 15, 2016 8:36 pm

Re: Trimix efficacy over time

Postby c0r5a38 » Sun Jan 06, 2019 11:19 am

Juts a minor update...the NP recommended an increase from 10 units to 12. The thought process is not so much tolerance buildup as much as a natural progression (regression?!) of my ED. Haven't had the opportunity yet :)
Diagnosed May 2012 with prostate cancer, 3.3 Gleason, active surveillance until February 2016 when biopsy result was Gleason 3.4. Radical prostatectomy performed by Dr. Peter Scardino at Sloane. Under Dr. Mulhill's care at Sloane for sexual health.

Cigar56
Posts: 575
Joined: Fri Aug 15, 2014 10:56 am

Re: Trimix efficacy over time

Postby Cigar56 » Sun Jan 06, 2019 5:32 pm

You're only injecting 10 unIts? You certainly should increase the amount of units. Keep moving up until you see a difference. The next step would be upping to a stronger formula.

You're not alone on your journey. I was once injecting 130 units -- yes, two needle pokes. My uro and I kept tweaking the formula until we started finding success. Even now I may step up one more level to the strongest formula available.

For some of us, Trimix is a lifelong journey.
62. Was under "active surveillance" for prostate cancer. Scheduled for prostate radiation -- Stereotactic Body Radiotherapy (SBRT) -- July 2019. Using pills and injections but not satisfied. Moving on to an implant via Medicare in 2022.

QuestionGuy
Posts: 103
Joined: Tue Sep 22, 2015 6:50 pm

Re: Trimix efficacy over time

Postby QuestionGuy » Sat Jan 19, 2019 1:10 pm

To answer the question on my own TRIMIX strength: i currently have 3 prescriptions from 2 different labs I'm trying:

30-10-60
25-3-80
30-2-60-1.5 (QUADMIX)

I now try 50 units on the syringe. Its very hard to get the injection to go smooth, as I think I'm hitting dense scar tissue now.

HISTORY: I did injections for 3 years and it was like being born again. I had amazing results!!! but I began to inject frequently, and I also did not compress the injection site for nearly 5 minutes each time (and I'm sure this lead to the massive scar tissue that accumulated). I did not find excusing myself to the bathroom to be that awkward - but I did find it awkward to still be compressing the injection site while the women was waiting in the other room, and that caused me to "rush the procedure". After dealing with the humiliation of ED, sticking a needle in my penis was nothing to be afraid of. If had it to do over , I do wish I had been upfront with "Some" of the women, especially when we saw each other regularly. They probably thought I was doing cocaine or had some kind of irritable bowel syndrome. Most of the time I kept up foreplay until "they" needed to excuse themselves to pee, and then I either went into another bathroom, or went right in as they came out of the one they were in (as if i too really needed to pee)

Anyway : If I combine 20mg cialis and moderate my drinking/masturbation, and I can get a decent injection where the liquid flows into my penis smoothly: I can still get a good erection, but it pivots at the base (so I have to guide it where I want it to go) I know this is a bit like a person saying they "can hear their stereo" if they turn up the volume &bass & treble to 10. It works right now....but it's not a good long term solution.
I'm 55. PostFinasterideSyndrome/Peyronies . Initially had good erections but numbness. Now erections are compromised, but good sensitivity. I see Dr. Irwin Goldstein and do : TRIMIX-Clomiphene-Arimidex –Cabergoline -Cialis -Traction-VED-Pshot-gainswave

FMLFML85
Posts: 93
Joined: Thu May 10, 2018 12:18 am

Re: Trimix efficacy over time

Postby FMLFML85 » Sat Jan 19, 2019 3:37 pm

@ questionguy
With you current method how long are your erections lasting? Does your erection go down at all when you cum or does it stay hard until the injection wears off?
33 years old, devorced. ED from abusing a penis pump. Pills having little effect, starting carverject theropudically june 13th


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