Bimix to Trimix jouney off with a thud

Sticking a needle Where? Courage, guidance and help.
Reggieman
Posts: 249
Joined: Sat Jun 04, 2016 7:17 pm
Location: Central California

Re: Bimix to Trimix jouney off with a thud

Postby Reggieman » Thu Oct 15, 2026 7:51 pm

Martin6469: Thanks for the information. I wasn't sure which one was causing the pain. I will contact my Urologist and see if he can suggest a different formulation. I turn 81 tomorrow, it is nice to hear from a Brother my age.
81 yrs. Retired. R.P. 2016. Bilateral nerve sparing surgery. Trimix twice weekly. Moderately incontinent. Anorgasmia. Electro-stim using Erostek ET-312 for minor orgasm. Peyronies. Type 2 diabetic, Pacemaker, grumpy attitude. Widower since 4/2026

Martin6469
Posts: 824
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Bimix to Trimix jouney off with a thud

Postby Martin6469 » Thu Oct 29, 2026 12:17 pm

Reggieman: I hope you can do remote consultations instead of driving that long distance. You have one more possibility if reformulation doesn't reduce the pain. You can add 100mg sildenafil to reduce the Trimix amount you need. But this has the danger of priapism and conservative doctors advise against it.

If you try it, have injectable phenylephrine handy or at least 120mg worth of phenylephrine capsules and ice cubes. You must start the titrating-up procedure all over again by taking the sildenafil an hour ahead to make sure it's all in your bloodstream. Then inject a quarter of the Trimix amount you have been using. That's all for that day. Three days later you again take the sildenafil and change the Trimix amount a little if you're going up, or a lot less if you got a four-hour erection. That's all for that day. In a few weeks you should arrive at your new and lower Trimix quantity.

Most of my length, on both sides, now has scar tissue. But a Franktalker last year pointed out that the corpora cavernosum extend some length into the body. So I've been successfully experimenting with injecting at the very base where I hadn't before. It's a trickier and I need a slightly longer needle, but it's nice to discover new territory!
Age 81 in 2026. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 25 min.

Martin6469
Posts: 824
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Bimix to Trimix jouney off with a thud

Postby Martin6469 » Thu Oct 29, 2026 12:19 pm

Reggieman: I hope you can do remote consultations instead of driving that long distance. You have one more possibility if reformulation doesn't reduce the pain. You can add 100mg sildenafil to reduce the Trimix amount you need. But this has the danger of priapism and conservative doctors advise against it.

If you try it, have injectable phenylephrine handy or at least 120mg worth of phenylephrine capsules and ice cubes. You must start the titrating-up procedure all over again by taking the sildenafil an hour ahead to make sure it's all in your bloodstream. Then inject a quarter of the Trimix amount you have been using. That's all for that day. Three days later you again take the sildenafil and change the Trimix amount a little if you're going up, or a lot less if you got a four-hour erection. That's all for that day. In a few weeks you should arrive at your new and lower Trimix quantity.

Most of my length, on both sides, now has scar tissue. But a Franktalker last year pointed out that the corpora cavernosum extend some length into the body. So I've been successfully experimenting with injecting at the very base where I hadn't before. It's a trickier and I need a slightly longer needle, but it's nice to discover new territory!
Age 81 in 2026. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 25 min.

Reggieman
Posts: 249
Joined: Sat Jun 04, 2016 7:17 pm
Location: Central California

Re: Bimix to Trimix jouney off with a thud

Postby Reggieman » Mon Nov 09, 2026 9:39 pm

Martin 6469: I wrote to my Urologist at UCSF advising him of the "ache" caused by the new Trimix formulation. I reached the recommended 20 units per injection but the ache was so bad I ended up taking an old Tramadol I had to avoid suffering for 3 or 4 hours. His reply was:

"You could consider pre-medicating with OTC pain meds but we are short on other formulations given that the less dilute stuff was not efficacious."

The formulation is 40 mcg + 2 mg + 30 mg, PGE-1-Phentolamine-Papaverine respectively. That formulation was just barely producing an erection sufficient for "penetration." That was a shock to hear as I have heard of many other formulations such as Quad mix, etc. Of course I don't know what's in the other formulations. Maybe my only alternative is an implant.

Now I have to consider whether, at my age of 81, whether to attempt to get an implant (I don't currently have a women in my life as my wife just died 6 months ago) or not. If I never get into a sexual relationship in the future will I have just wasted time, pain and money.
81 yrs. Retired. R.P. 2016. Bilateral nerve sparing surgery. Trimix twice weekly. Moderately incontinent. Anorgasmia. Electro-stim using Erostek ET-312 for minor orgasm. Peyronies. Type 2 diabetic, Pacemaker, grumpy attitude. Widower since 4/2026

CanGetItUpButNotOff
Posts: 543
Joined: Mon Sep 20, 2021 1:34 pm

Re: Bimix to Trimix jouney off with a thud

Postby CanGetItUpButNotOff » Tue Nov 10, 2026 8:45 am

Hi, Reggieman. So sorry to hear that your wife has recently passed. I hope that you do find another suitable "outlet" for your erection. Without regard to age, I would pull out all the stops to be able to perform, whether that be with super levels of injection or, eventually, an implant. I don't have signs of fibrosis, but if I did I would jab that dick as many times as necessary to get the TriMix or BiMix into the corpora cavernosa.

I appreciate all of the contributions made by Martin6469, but I'm going to give a dissenting view on the TriMix formulation that might cause ache. All the information I've ever seen over the years is that the ingredient that causes ache is alprostadil. That's why BiMix is composed of papaverine and phentolamine. Find a urologist -- at UCSF or elsewhere -- that will give you a BiMix prescription and keep the experiment going. I agree with the titrating instructions given by Martin6469 -- the idea of adding sildenafil and titrating up.

When experimenting with those, I consider it mandatory to have liquid phenylephrine on hand to ward off priapism without going to the ER. It's also a good idea to have pseudoephedrine (generic for Sudafed) pills handy -- 120 mg is a good dose. [Note the difference: the liquid is phenylephrine but the pills are pseudoephedrine. Don't confuse the two.] Near-priapism rarely is a problem for me these days, but when it is, at 2½ hours I'll take the pseudoephedrine pills and then, if needed, at 3 1/2 hours I'll infect the phenylephrine.

Don't give up!
Born 1954. Diabetes, hypertension, atherosclerosis, MI. Sildenafil became ineffective. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend so far. Daily Cialis. Tried LiESWT 13 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy.


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