Combination Therapy - Tablets + ICI

[WestLad]

What impact does Cialis / Tadalafil (or equally Viagra / Sildenafil) have on your injection?

Does it have a minor / major impact for you?

I’m assuming that any effect does not create a risk of a 4 hour erection.

[CanGetItUpButNotOff]

I take a 10 mg Tadalafil daily to augment my ICI. The Tadalafil isn't sufficient for me to have intercourse and I'm not even sure it does a lot to help erections. But I am convinced it is a good general Health measure and if it helps the ICI do its job, then that means potentially less chemical injected into my corpora cavernosa.

To avoid priapism, I do think it's important to keep the baseline of any PDE5 that you use consistent so that the ICI is being used against a known vasodilation state. You don't want to dial in the ICI dose and then have the results jump around because the PDE5 is changing.

[WestLad]

I take a 10 mg Tadalafil daily to augment my ICI. The Tadalafil isn't sufficient for me to have intercourse and I'm not even sure it does a lot to help erections. But I am convinced it is a good general Health measure and if it helps the ICI do its job, then that means potentially less chemical injected into my corpora cavernosa.

To avoid priapism, I do think it's important to keep the baseline of any PDE5 that you use consistent so that the ICI is being used against a known vasodilation state. You don't want to dial in the ICI dose and then have the results jump around because the PDE5 is changing.

I have a very low response to all ED tablets

[Martin6469]

I use 100mg sildenafil with Trimix - this cuts the amount of Trimix I need about in half.

But if you want to do this you must avoid priapism by starting low and carefully titrating up the Trimix amount as you did when first beginning injections. You do this by first taking the sildenafil 45-75 minutes before injecting, to make sure it's all in your bloodstream. Forty-five minutes if your stomach is empty and an hour or more if not.

After my lengthy titrating-up experiments, I can now dial up any erection duration.

[LeTigre88]

I use 100mg sildenafil with Trimix - this cuts the amount of Trimix I need about in half.

But if you want to do this you must avoid priapism by starting low and carefully titrating up the Trimix amount as you did when first beginning injections. You do this by first taking the sildenafil 45-75 minutes before injecting, to make sure it's all in your bloodstream. Forty-five minutes if your stomach is empty and an hour or more if not.

After my lengthy titrating-up experiments, I can now dial up any erection duration.

Yes, Martin, good post- I have explored the same path with good results.
Must note my perpective re the experiment calculation of the pills on a full stomach. In my long experience, any significant food in the stomach really delays- and inhibits overall-- the response to pills significantly, vs empty stomach. Not sure how this plays out in the potential interaction.
And because we are warned about doing this, we are assuming here we are talking to peeps for whom the pills even in high doses are only minimally effective.

That being said, I have been doing this lately and feel I have it dialed in as well.
I'm using 25-50mg of V, empty stomach, then an hour later use half usual dose of injectable. I like this erection a bit better- maybe not as hard overall, and a very slight waxing and waning based on stimulation, but generally when I get it right I find there is more overall engorgement, vs just the corpora.