Combination Therapy - Tablets + ICI

Sticking a needle Where? Courage, guidance and help.
WestLad
Posts: 38
Joined: Tue Nov 12, 2024 1:24 pm

Combination Therapy - Tablets + ICI

Postby WestLad » Mon May 11, 2026 8:02 am

What impact does Cialis / Tadalafil (or equally Viagra / Sildenafil) have on your injection?

Does it have a minor / major impact for you?

I’m assuming that any effect does not create a risk of a 4 hour erection.
UK. 70 years old.
Type 2 diabetes
ED since 2010

CanGetItUpButNotOff
Posts: 478
Joined: Mon Sep 20, 2021 1:34 pm

Re: Combination Therapy - Tablets + ICI

Postby CanGetItUpButNotOff » Mon May 11, 2026 8:22 am

I take a 10 mg Tadalafil daily to augment my ICI. The Tadalafil isn't sufficient for me to have intercourse and I'm not even sure it does a lot to help erections. But I am convinced it is a good general Health measure and if it helps the ICI do its job, then that means potentially less chemical injected into my corpora cavernosa.

To avoid priapism, I do think it's important to keep the baseline of any PDE5 that you use consistent so that the ICI is being used against a known vasodilation state. You don't want to dial in the ICI dose and then have the results jump around because the PDE5 is changing.
Born 1954. Diabetes, hypertension, atherosclerosis. Sildenafil iffy. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend pending long-term efficacy. Daily Cialis. Tried LiESWT 4 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy

WestLad
Posts: 38
Joined: Tue Nov 12, 2024 1:24 pm

Re: Combination Therapy - Tablets + ICI

Postby WestLad » Mon May 11, 2026 9:40 am

CanGetItUpButNotOff wrote:I take a 10 mg Tadalafil daily to augment my ICI. The Tadalafil isn't sufficient for me to have intercourse and I'm not even sure it does a lot to help erections. But I am convinced it is a good general Health measure and if it helps the ICI do its job, then that means potentially less chemical injected into my corpora cavernosa.

To avoid priapism, I do think it's important to keep the baseline of any PDE5 that you use consistent so that the ICI is being used against a known vasodilation state. You don't want to dial in the ICI dose and then have the results jump around because the PDE5 is changing.


I have a very low response to all ED tablets
UK. 70 years old.
Type 2 diabetes
ED since 2010

Martin6469
Posts: 781
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Combination Therapy - Tablets + ICI

Postby Martin6469 » Wed May 13, 2026 1:42 pm

I use 100mg sildenafil with Trimix - this cuts the amount of Trimix I need about in half.

But if you want to do this you must avoid priapism by starting low and carefully titrating up the Trimix amount as you did when first beginning injections. You do this by first taking the sildenafil 45-75 minutes before injecting, to make sure it's all in your bloodstream. Forty-five minutes if your stomach is empty and an hour or more if not.

After my lengthy titrating-up experiments, I can now dial up any erection duration.
Age 80 in 2025. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.


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