New to trimix ended up in ER

Sticking a needle Where? Courage, guidance and help.
Pfisher101
Posts: 1
Joined: Mon Dec 01, 2025 3:29 pm

New to trimix ended up in ER

Postby Pfisher101 » Tue Jan 27, 2026 11:42 am

I just started trimix last week and ended up in the ER with a 7 hour erection. I did my first injection on Friday with a dose of .05ml. This was the recommended starting dose. It worked ok-ish. Saturday I injected again, this time .04. It did not work too well. I took Sunday off and tried again Monday with .06. This dosage landed me in the ER. I was surprised such a small increase made such a difference, especially since the notes from my provider said to increase in .03 ml increments up to .12 ml if needed. Sudafed did nothing and I did not have the phenylephrine. I have ordered phenylephrine And will not be injecting again until it arrives. What did I do wrong? Were my injections too close together? I followed instructions of to wait at least 24 hours and no more than 3 injections in a week (admittedly, I grouped my three pretty close together). Did I try to increase by too much? I appreciate any feedback from those more experienced with this. Thanks!!!

Lawnman
Posts: 70
Joined: Thu Sep 22, 2022 4:47 pm

Re: New to trimix ended up in ER

Postby Lawnman » Tue Jan 27, 2026 1:36 pm

Whoa.
It is difficult to explain why you would get such a reaction after increasing a dose by .01. Maybe you should consider switching to Bimix? Talk to your doctor.

Budward
Posts: 374
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: New to trimix ended up in ER

Postby Budward » Tue Jan 27, 2026 1:54 pm

One should never inject without having phenylephrine available. Rookie mistake, now you have learned.

User avatar
GoodWood
Posts: 1520
Joined: Sun Jun 16, 2019 1:07 pm

Re: New to trimix ended up in ER

Postby GoodWood » Tue Jan 27, 2026 2:39 pm

Wow, I’m really sorry to hear that. It does sound like a small silver lining that your ER visit didn’t involve needles to drain your penis—that’s definitely a relief.

The main issue, as I see it, is that this formulation is extremely strong for you. When you’re injecting 4, 5, or 6 units, those are tiny differences that are very hard to measure accurately.

I’d talk with your doctor about prescribing a mix that’s about half—or even a third—as potent. In my experience, a dose in the 10–15 unit range was the sweet spot: large enough that a one-unit measuring error wasn’t catastrophic, but still strong enough to get plenty of injections out of a vial.
57yo, NYC. ED started at 40. Pills, then shots for 10 years. 24cm Coloplast Titan XL w/classic pump by Dr Eid 3/25/2025. Will meet for show & tell.
Implant journal: [url] viewtopic.php?f=6&t=26225[/url]

User avatar
ElbowRoom
Posts: 909
Joined: Mon Mar 17, 2025 1:58 pm

Re: New to trimix ended up in ER

Postby ElbowRoom » Tue Jan 27, 2026 2:55 pm

Budward wrote:One should never inject without having phenylephrine available. Rookie mistake, now you have learned.


I injected over a decade without it, my urologist never even mentioned it. Sudafed worked for me, I never ended up in the ER.

I wouldn’t call it a rookie mistake.
58yo Coloplast Titan 28cm Penoscrotal with Dr. Hakky 10/21/2025.
Pre-op erect measurements:
8.5"L and 6.5"C

Post-op: 8”L and 6”C at one week.
8.5” and 6”C at three weeks with full glans engorgement

Budward
Posts: 374
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: New to trimix ended up in ER

Postby Budward » Tue Jan 27, 2026 3:51 pm

I have never had to use mine either, usually a Sudafed or two helps if I am starting to feel stress. However I have had the antidote available since day 1. Never want to go to an ER with a four hour erection. The newspaper yes!

John Dday
Posts: 95
Joined: Thu Sep 05, 2024 8:30 pm

Re: New to trimix ended up in ER

Postby John Dday » Tue Jan 27, 2026 5:47 pm

Wow, Thats a worry. I use Alprostadil on it's own (one of the ingreadants of Trimix) Trimix is made in very different strenghs. I wonderif human error in the lab could be the problem. I wouldnt use this batch again, until it is tested.
1955. I have had ED for years. We were planning to go for a Rigi10 in October 2024. Life got in the way (heart attack & stent), so we are now going for injections as a fill-in. 9/2025 More life roadblocks with prostate Cancer:((

CanGetItUpButNotOff
Posts: 442
Joined: Mon Sep 20, 2021 1:34 pm

Re: New to trimix ended up in ER

Postby CanGetItUpButNotOff » Tue Jan 27, 2026 9:16 pm

Just throwing some spitlbals at the problem…

Any new injector is going to have an injection learning curve so I'd say it's likely a miss or partial miss with the needle that gives varying results. It has helped me to plump up the target before injecting to get a good target.
Born 1954. Diabetes, hypertension, atherosclerosis. Sildenafil iffy. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend pending long-term efficacy. Daily Cialis. Tried LiESWT 4 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy

Sean762
Posts: 161
Joined: Thu Jul 22, 2021 11:07 pm

Re: New to trimix ended up in ER

Postby Sean762 » Fri Feb 06, 2026 7:42 pm

Budward wrote:One should never inject without having phenylephrine available. Rookie mistake, now you have learned.

Phenylephrine isn't a magic panacea. I was injected 2 (or was it 3?) times with my Tri-mix 105 induced priapism in the ER....to NO effect. Had to have my penis physically drained with a 14 gauge needle. Horrific.

RJ_in_Pa
Posts: 155
Joined: Tue Oct 17, 2023 4:34 pm
Location: Pa

Re: New to trimix ended up in ER

Postby RJ_in_Pa » Sat Feb 07, 2026 8:39 am

Wow! 7 hours, that’s brutal! So sorry to hear that.

I have to agree with …ButNotOff that you likely didn’t hit the sweet spot on prior attempts. I too plump up to get a larger target before injecting.

My second thought, are you sure you using the right sized needle and filling the needle properly. Almost sounds like when you think you are incrementing by .01, you are incrementing by 10? Just a thought.

Can you check with your Dr or maybe even post a pic of the needle set where think you are at .05?

RJ
65, Radical Prostatectomy in 2023, pills did nothing. Currently on Trimix with great success.


Return to “Injections”

Who is online

Users browsing this forum: ClaudeBot and 39 guests