New to trimix ended up in ER

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Pfisher101
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Joined: Mon Dec 01, 2025 3:29 pm

New to trimix ended up in ER

Postby Pfisher101 » Tue Jan 27, 2026 11:42 am

I just started trimix last week and ended up in the ER with a 7 hour erection. I did my first injection on Friday with a dose of .05ml. This was the recommended starting dose. It worked ok-ish. Saturday I injected again, this time .04. It did not work too well. I took Sunday off and tried again Monday with .06. This dosage landed me in the ER. I was surprised such a small increase made such a difference, especially since the notes from my provider said to increase in .03 ml increments up to .12 ml if needed. Sudafed did nothing and I did not have the phenylephrine. I have ordered phenylephrine And will not be injecting again until it arrives. What did I do wrong? Were my injections too close together? I followed instructions of to wait at least 24 hours and no more than 3 injections in a week (admittedly, I grouped my three pretty close together). Did I try to increase by too much? I appreciate any feedback from those more experienced with this. Thanks!!!

Lawnman
Posts: 70
Joined: Thu Sep 22, 2022 4:47 pm

Re: New to trimix ended up in ER

Postby Lawnman » Tue Jan 27, 2026 1:36 pm

Whoa.
It is difficult to explain why you would get such a reaction after increasing a dose by .01. Maybe you should consider switching to Bimix? Talk to your doctor.

Budward
Posts: 373
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: New to trimix ended up in ER

Postby Budward » Tue Jan 27, 2026 1:54 pm

One should never inject without having phenylephrine available. Rookie mistake, now you have learned.

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GoodWood
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Joined: Sun Jun 16, 2019 1:07 pm

Re: New to trimix ended up in ER

Postby GoodWood » Tue Jan 27, 2026 2:39 pm

Wow, I’m really sorry to hear that. It does sound like a small silver lining that your ER visit didn’t involve needles to drain your penis—that’s definitely a relief.

The main issue, as I see it, is that this formulation is extremely strong for you. When you’re injecting 4, 5, or 6 units, those are tiny differences that are very hard to measure accurately.

I’d talk with your doctor about prescribing a mix that’s about half—or even a third—as potent. In my experience, a dose in the 10–15 unit range was the sweet spot: large enough that a one-unit measuring error wasn’t catastrophic, but still strong enough to get plenty of injections out of a vial.
57yo, NYC. ED started at 40. Pills, then shots for 10 years. 24cm Coloplast Titan XL w/classic pump by Dr Eid 3/25/2025. Will meet for show & tell.
Implant journal: [url] viewtopic.php?f=6&t=26225[/url]

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ElbowRoom
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Joined: Mon Mar 17, 2025 1:58 pm

Re: New to trimix ended up in ER

Postby ElbowRoom » Tue Jan 27, 2026 2:55 pm

Budward wrote:One should never inject without having phenylephrine available. Rookie mistake, now you have learned.


I injected over a decade without it, my urologist never even mentioned it. Sudafed worked for me, I never ended up in the ER.

I wouldn’t call it a rookie mistake.
58yo Coloplast Titan 28cm Penoscrotal with Dr. Hakky 10/21/2025.
Pre-op erect measurements:
8.5"L and 6.5"C

Post-op: 8”L and 6”C at one week.
8.5” and 6”C at three weeks with full glans engorgement

Budward
Posts: 373
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: New to trimix ended up in ER

Postby Budward » Tue Jan 27, 2026 3:51 pm

I have never had to use mine either, usually a Sudafed or two helps if I am starting to feel stress. However I have had the antidote available since day 1. Never want to go to an ER with a four hour erection. The newspaper yes!


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