Refreezing drawn needles

[Nocturne]

I feel like there is a lot of confusion about this.
I’m getting a new vial of Trimix, some phenylephrine, and some needles shipped to me.
I’m not planning to use it more than once a month or so.
I have heard of people drawing needles (one dose) and refreezing them for later use.
Nurse practitioner I initially saw indicated that was a no-go.
Doc later told me some of his patients do it and didn’t advise against it.
Pharmacy told me NOT to refreeze needles or even put them back in the fridge because they “lose potency” after being taken out of the vial.
What is the deal here? Is this a thing that is effective to do or not? Is it dangerous somehow?
Again, I plan to use this stuff once a month or so and would rather not be ponying up the dough for a whole new vial every time.
Edit: I did some reading and it looks like the issue is with REFREEZING trimix after it has already been frozen and thawed once. Called pharmacy and confirmed that they only refrigerate it before shipping. So - I can freeze it in drawn needles so long as I only freeze it once?

[GoodWood]

The loss of potency of prostaglandin—the component of TriMix that’s said to degrade at room temperature—is greatly overstated.

I kept vials refrigerated (not frozen) for extended periods, often months at a time, and noticed no loss of potency. The last injection from a vial worked just as well as the first, and no differently from the first injection of the next vial.

I did try freezing once, since it seemed like a good idea. I pre-filled several syringes, placed them in a baggie, and stored them in the freezer. When it was time to inject, I’d take one out, and it would thaw within a few minutes.

However, I ran into a significant problem: the needles on those syringes became clogged. I would already have the needle inserted, but the plunger wouldn’t depress. Wrestling with a stuck syringe while the needle is inside your penis is extremely difficult. When I removed the needle, there was no way to get the medication to flow—the needle was completely blocked.

My suspicion is that one of the components precipitated out of solution during freezing or thawing, forming a solid plug inside the needle.

I know others have frozen and thawed TriMix without any issues, and I believe them. In my case, the medication was very concentrated, and I was using a relatively high dose at that point, which may have contributed to the problem.

Because of that experience, I stopped freezing altogether and simply kept the medication refrigerated.

Based on my experience, whether you freeze or refrigerate doesn’t make a meaningful difference in potency.

[Nocturne]

Based on my experience, whether you freeze or refrigerate doesn’t make a meaningful difference in potency.

Thanks for the info! I’m sure I have a long road of discovery ahead. Eventually I’m sure things will fall into place. It feels like the system is not built around providing Trimix for special occasions, but rather weekly use.

I noticed your age of onset was close to my own (41). Can I ask what caused your ED at such a young age? I wonder how much like yours my trajectory will be. I’m fairly optimistic about the mid future (5 years from now or so), but I also have a feeling that I’ll never really feel “cured” until I get the implant.

Edit: Just noticed your ED journal - will read that!

[GoodWood]

Can I ask what caused your ED at such a young age?…

Happy to tell you about it. But so we don’t get this thread about freezing TriMix off-track I’ll send you a PM.

[CanGetItUpButNotOff]

However, I ran into a significant problem: the needles on those syringes became clogged. I would already have the needle inserted, but the plunger wouldn’t depress. Wrestling with a stuck syringe while the needle is inside your penis is extremely difficult. When I removed the needle, there was no way to get the medication to flow—the needle was completely blocked.

My suspicion is that one of the components precipitated out of solution during freezing or thawing, forming a solid plug inside the needle.

I very successfully freeze my syringes/needles. I put a little extra in each syringe then pull back the plunger to give some room for expansion. When it's time to inject, I cycle the plunger a little bit and squeeze out the excess solution. This makes sure the plunger moves freely and that the solution is not clogging the needle. With GoodWood's experience, I think I'll add a step to keep the syringes upright until they freeze so that there is no solution frozen into the actual needle part.

GoodWood - do you think that process would have avoided the precipitation you observed?

[GoodWood]

…GoodWood - do you think that process would have avoided the precipitation you observed?

I’m not sure. I tried a couple times. After the first experience of the gummed up frozen/thawed syringes I filled the next batch and drew in a little air bubble so the needle wouldn’t have medication in it.

And it’s not EVERY syringe that didn’t work. But probably every third one didn’t work.

After that I gave up on it and just stuck to refrigeration. I didn’t ever notice degradation of effect in my mixes so I determined it wasn’t necessary.

But I know others, like yourself, haven’t had the same problem I had.