Moving forward after priapism

Sticking a needle Where? Courage, guidance and help.
Nocturne
Posts: 176
Joined: Fri Oct 28, 2016 11:59 pm

Moving forward after priapism

Postby Nocturne » Sun Dec 28, 2025 9:19 am

So it’s been 2-3 weeks since my priapism sent me to the ER for a pretty unpleasant experience. I don’t think any serious damage was done - blood oxygenation was at 80% at the seven hour mark when they drained it - which is good.
I was told not to use Trimix again until after meeting with my urologist, which will be happening on the 12th of January.
In the meantime been having mixed success with the usual Cialis. Pretty good experience yesterday morning. I know my issue is “primarily” psychogenic, as in I can get pretty good erections (strong enough to hang a towel on) on my own with Cialis, and have not had any mishaps with masturbation in years - it’s when I’m with my wife that trouble can happen.
I started Trimix because I was in a psychogenic slump after another bad experience in a hotel room on vacation back in April or so. My goal was to have a new trick up my sleeve for vacations so that might never happen again, plus some special occasion nights at home (maybe once a month?) where I could cut loose and try positions other than the two scripted ones we use every time. Would be nice to feel confident enough to switch positions during sex again, take her from behind, maybe even standing up in the shower.
After this incident I am not so sure. Should I stop? Was this it for Trimix for me? I only used it maybe half a dozen times.
I suspect that maybe I wasn’t hitting the right spot on previous attempts, as low dose (10 units) didn’t do much of anything, and up to 30 units produced “erections with stimulation” that went down immediately after orgasm. Then the most recent time at 32 units I was still hard seven hours later! How could 2 units of made such a difference? Plus I noticed that my previous attempts would leave me with an ache and swelling (almost a “lump” on or near the injection site) that lasted for close to a day afterwards, and a bend in my penis that was consistently AWAY from the injection side, whichever one that was. None of that happened with the most recent injection that led to priapism.
The injections still feel inconvenient to me - timing, keeping the Trimix “fresh” by freezing and trying to juggle how to store it frozen or cold, the fact that the fridge I keep it in is as far away from our bedroom as possible and I have to take a “walk of shame” through the entire house to get to it with a needle, fill up the needle in the basement, and take it upstairs for injection… eh.
But I’m thinking I should try to stick with it. Maybe get a mini fridge for the bedroom. This isn’t something I am going to need for most of my sexual encounters, and I know that. I just want it in my back pocket for when there is trouble, and when I know anxiety will be high (vacations), and also maybe to cut loose every now and then and just not have to worry. But of course now the worry will be priapism.
Any thoughts or suggestions or any other kind of insight?
Genetically sky-high Lp(a) of 390 led to various heart diseases. Ultra-low testosterone of 120 (now 480 with Clomid) also contributed to ED at age 41. Managing with daily Cialis, but for me, the implant is a "when", not an "if".

CanGetItUpButNotOff
Posts: 420
Joined: Mon Sep 20, 2021 1:34 pm

Re: Moving forward after priapism

Postby CanGetItUpButNotOff » Sun Dec 28, 2025 12:27 pm

You seem to have a lot of issues, but to the point, I think you should keep trying with TriMix.

My guess is that you are having trouble really getting the needle into the cavernosum. What has greatly helped me is to put on some type of cock ring and plump up my penis, either my myself or with my wife's help (oral is best!). This swells the cavernosum and gives a big target. I also aspirate a little blood to verify correct placement. This has been 100% solid for me. I use a 31ga 8mm needle. What are you using?

Rather than experiment with it occasionally, use it for several times in a real to get a real feel for the injection prices and to gauge its effectiveness over time.

In another thread. @Budwsrd and I encouraged you to get phenylephrine to ease your mind about the priapism. You have stated several times that you like and have confidence in your urologist. But if he won't give you phenylephrine… run as fast as you can to a better urologist. With your history, you MUST MUST have phenylephrine before you take your next shot.

If you're getting lumps, bumps and pain then maybe Bimix or straight Alprostadil is better for you. I've never had any of these symptoms and never tried Bimix or Alprostadil so take this as an uninformed opinion.

You're overthinking keeping the solution frozen or cold. I keep mine pre-loaded (actually several at a time) in a needle frozen until the day of use when I move it to the refrigerator. I find it convenient to leave the bedroom to shoot up in the kitchen. But if that's not the case for you, I'd try this protocol: keep a syringe(s) in the freezer and when it's looking like "go time" move it from the freezer to your bedroom or bathroom and let it sit at ambient temperature for any where from 2 hours to 10 minutes. It will be ready to go and perfectly well preserved. The key is to prefill the syringe(s) days in advance so you have a frozen supply at the ready.
Born 1954. Diabetes, hypertension, atherosclerosis. Sildenafil iffy. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend pending long-term efficacy. Daily Cialis. Tried LiESWT 4 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy


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