Is my trimix still good after thawing?

[macoza]

I bought trimix in April of this year stored in the freezer with expiration of August 4th. I have 2 questions...

1) I used it 4 times in total. A few days ago I took it out the freezer to thaw it almost completely to check for fogginess to check for effectiveness. No fogginess. I put it back in the freezer. Although it was out of the freezer for 10 minutes thawed, is it still good? Would the 10 minutes of it being thawed make it useless?

2) As I said, I bought it in late April with expiration of August 4th. I plan to use it next week. Will it still be effective being close to the expiration date?

[macoza]

Bump

[bldoink]

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[Young-at-heart]

My pharmacy gives it 6 months as an "expiry Date". I've gone beyond by a month with no noticeable impact. I thaw it, take a dose and refreeze it many time in between.

[Martin6469]

Expiration dates of a few months are fictitious. I never freeze Trimix - I've used Trimix refrigerated at 40F (4C) for 10 months with no change in effectiveness.

[qcswral]

My pharmacy gives it 6 months as an "expiry Date". I've gone beyond by a month with no noticeable impact. I thaw it, take a dose and refreeze it many time in between.

This is my routine as well...I keep it frozen and thaw it to make up about 10 syringes.. I re-freeze the Quad-Mix vial and the syringes I won't be using that day. Haven't had or noticed a problem....I have had some Trimix batches that after 6 months the efficacy seemed to drop off...but I've also had batches that seemed to do the trick after 1 year. I sometimes think that happens due to several factors out of my control from the compound pharmacy...For example; potency of the 3 medications (or 4 for Quad-mix) as well as the age of their medications on hand that they use to create the Trimix/Quad-mix formula.

[CanGetItUpButNotOff]

I've only used one batch of Tri-Mix since it was initially prescribed for me 9 months ago. My routine is to freeze it, and then thaw it for about 10 syringes worth, then refreeze it. I recently traveled for about a month with it so it has gone through a thaw cycle during that travel time that may test whether or not it's still efficacious.