New Treatment???

Anything goes when it comes to ED.
hoosierphilly
Posts: 132
Joined: Mon Mar 14, 2011 11:08 am

New Treatment???

Postby hoosierphilly » Thu Jan 09, 2014 6:09 pm

I plan to see if the Alpha-Stim (from Texas) will aid my ED! I have stents (not in the penis), and Type 2 diabetes, and ED recently if performance with discomfort????

Any thoughts out there.


Shock waves may improve penile vasculature.
LYON, FRANCE—Israeli researchers have reported promising preliminary results using low-intensity shock wave therapy to treat vasculogenic erectile dysfunction (ED).

In fact, 15 of 20 patients with mild or moderate ED who have been treated thus far had a significant improvement in erectile function and in most cases were able to discontinue treatment with phosphodiesterase-5 (PDE-5) inhibitors. There were no reports of pain or other adverse effects.

Yoram Vardi, MD, chief of the neuro-urology unit at Rambam Medical Center in Haifa, presented the findings here at the annual meeting of the European Society for Sexual Medicine.

Low-energy shock wave therapy is being increasingly used to induce regeneration of small coronary vessels in patients with angina who are not suitable for coronary surgery or angioplasty, Dr. Vardi explained.

His group had hypothesized that if the therapy can improve the vasculature of the heart, it might also be effective in the penis because 80% of ED cases are of vascular origin.

Participants in the trial had a score of 12 to 20 on the Erectile Function domain of the International Index of Erectile Function (IIEF-ED) and abnormal nocturnal penile tumescence (NPT). In all cases, ED had a vascular origin. The mean duration of ED was 35 months.

During each treatment session, low-energy shock wave therapy was applied on the penile shaft and crus for three minutes in each of five anatomical sites. The shock waves were are one-tenth the level of intensity as the shock waves used to pulverize kidney stones.

The men underwent a three-week course of two weekly treatment sessions and a second identical round of therapy starting three weeks later. Erectile function was assessed at the time of enrollment and four weeks after the end of treatment.

“The protocol used to enhance vasculogenesis of the ischemic heart is the same one we used to treat ED,” Dr. Vardi said.

Results showed that the IIEF-ED score improved by more than five points in 15 patients (75%). Seven of 20 patients (35%) had an improvement of more than 10 points.

Six-month follow-up data show that 12 of the 15 patients who improved significantly with treatment said they no longer needed to use PDE-5 inhibitors to treat their condition.

Scores on several other validated ED questionnaires including Quality of Erection Questionnaire, Self-Esteem and Relationship Questionnaire, and Erectile Dysfunction Inventory of Treatment Satisfaction also improved significantly.

The analysis additionally showed a significant improvement in baseline and maximal flow values on a penile endothelial function test.

“We are very excited by our findings but it's important to emphasize that they are preliminary and that further evaluation is needed using sham control and long-term follow-up,” Dr. Vardi said. “And what has been especially gratifying is that patients have told us that they are very pleased with the results and they tell us that they are again having morning erections and that they can perform better.”

From the January 2010 Issue of Renal And Urology News »


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This coverage is not sanctioned by, nor a part of, the European Association of Urology.




Medscape Medical News

Penile Shock Wave Therapy Helps Men With Severe Erectile Dysfunction

Jill Stein
March 22, 2011









Editors' Recommendations
•Phosphodiesterase Inhibitors in Clinical Urology
•Assessing Satisfaction in Men and Their Female Partners After Treatment With Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction
•Zotarolimus-Eluting Peripheral Stents for the Treatment of Erectile Dysfunction in Subjects With Suboptimal Response to Phosphodiesterase-5 Inhibitors



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Drug & Reference Information
•History Taking in the Erectile Dysfunction Patient
•Physiology of Erectile Dysfunction
•Erectile Dysfunction








March 22, 2011 (Vienna, Austria) — Low-intensity shock wave therapy to the penis can help men with severe erectile dysfunction (ED) that is unresponsive to conventional phosphodiesterase type 5 (PDE-5) inhibitor treatment, according to data released here at the European Association of Urology 26th Annual Congress.

"Our earlier randomized double-blind placebo-controlled study demonstrated that low-intensity shock wave therapy can help men who respond to PDE-5 inhibitor therapy, and our new data show that the treatment is also beneficial when given to nonresponders with severe ED," Yoram Vardi, MD, head of the neuro-urology unit at Rambam Medical Center in Haifa, Israel, told Medscape Medical News.







Dr. Yoram Vardi

The new findings confirm that the treatment exerts a genuine physiological effect on the erectile mechanism when applied directly to the cavernosal tissue, he added.

Dr. Vardi reported results in 29 men with vasculogenic ED who had a mean baseline International Index of Erectile Function (IIEF-ED) domain score of 8.8 and a rigidity score of 2 or lower. Their mean age was 62.8 years.

"While the introduction of PDE-5 inhibitors undeniably represents a major advance in ED treatment, these agents are a symptomatic treatment and are associated with unpleasant side effects and poor compliance," Dr. Vardi said. "These limitations become magnified when the treatment is intended for a pleasurable biological function rather than a life-threatening disease."

Rationale for Shock Wave Therapy in ED

Low-energy shock wave therapy is being increasingly used to induce the regeneration of small coronary vessels in patients with angina who are not suitable for coronary surgery or angioplasty, Dr. Vardi explained.

If the therapy can improve the vasculature of the heart, it might also be effective in the penis, because 80% of ED cases have a vascular origin, he said.

The shock wave therapy protocol involved 2 treatment sessions per week for 3 weeks, which were then repeated 3 weeks later.

During each treatment session, low-energy shock wave therapy was applied to the penile shaft and crus for 3 minutes in 5 different penile anatomical sites. The shock waves are one tenth the level of intensity as shock waves used to pulverize kidney stones.

Patients had a follow-up assessment at 1 month, when they were not receiving a PDE-5 inhibitor, and again at 2 months, when they were receiving active on-demand PDE-5 inhibitor therapy.

The coprimary end points were changes on the IIEF-ED domain score and penile rigidity score.

Significant Improvement

At the end of the study, 21 patients (72.4%; P < .0001) achieved a rigidity score of 3 or higher, meaning they were able to achieve full vaginal penetration.

The mean IIEF-ED domain score of the participants increased to 18.8 ± 1.1 (P < .0001). For 22 patients (75.9%), the IIEF-ED domain scores were increased by 5 or more points, and the average improvement for all 30 patients exceeded 10 points. The erectile function of 8 patients had normalized at the second follow-up visit, and patients were able to function sexually without the use of medication.

In addition, all 3 hemodynamic penile parameters (maximum flow-mediated dilation [FMD]) and area under the curve FMD significantly increased (P = .0001) and were significantly associated with an increase in IIEF-ED domain scores (P < .05).

There were no complaints of pain related to treatment, and no adverse events were reported during follow-up.

"The findings mean that low-intensity shock wave therapy was able to convert most nonresponders into PDE-5 inhibitor responders, thereby enabling men who were not functioning sexually to now achieve vaginal penetration and full intercourse," Dr. Vardi observed.

Importantly, the 21 diabetic patients in this series had significant improvement in ED. "These men are normally very difficult to treat," he said.

Elsewhere at the meeting, Dr. Vardi reported that the results from the first randomized sham-controlled study demonstrated that the application of the device directly to the penis has a significant effect on erectile mechanism and hemodynamics, compared with the sham intervention.




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Ther Adv Urol. 2013 Apr;5(2):95-9. doi: 10.1177/1756287212470696.

Shockwave treatment of erectile dysfunction. from pubmed.gov

Gruenwald I, Appel B, Kitrey ND, Vardi Y.


Author information

•Neuro-Urology Unit, Rambam Medical Center and Rappaport Faculty of Medicine, Technion, Haifa 34679, Israel.


Abstract


Low-intensity extracorporeal shock wave therapy (LI-ESWT) is a novel modality that has recently been developed for treating erectile dysfunction (ED). Unlike other current treatment options for ED, all of which are palliative in nature, LI-ESWT is unique in that it aims to restore the erectile mechanism in order to enable natural or spontaneous erections. Results from basic science experiments have provided evidence that LI-ESWT induces cellular microtrauma, which in turn stimulates the release of angiogenic factors and the subsequent neovascularization of the treated tissue. Extracorporeal shock wave therapy (ESWT) has been clinically investigated and applied in several medical fields with various degrees of success. High-intensity shock wave therapy is used for lithotripsy because of its focused mechanical destructive nature, and medium-intensity shock waves have been shown to have anti-inflammatory properties and are used for treating a wide array of orthopedic conditions, such as non-union fractures, tendonitis, and bursitis. In contrast, LI-ESWT has angiogenetic properties and is therefore used in the management of chronic wounds, peripheral neuropathy, and in cardiac neovascularization. As a result of these characteristics we initiated a series of experiments evaluating the effect of LI-ESWT on the cavernosal tissue of patients with vasculogenic ED. The results of our studies, which also included a double-blind randomized control trial, confirm that LI-ESWT generates a significant clinical improvement of erectile function and a significant improvement in penile hemodynamics without any adverse effects. Although further extensive research is needed, LI-ESWT may create a new standard of care for men with vasculogenic ED.


KEYWORDS:

erectile dysfunction, male impotence, shockwaves, therapy


PMID:23554844[PubMed] PMCID:PMC3607492Free PMC Article


Dr. James Catto

"The biggest problem with ED treatments is that the tablets are used on an on-demand basis and don't work for a proportion of patients; that proportion may be 30% or 70%, depending on the population and the prescribing physician," James Catto, MB ChB, PhD, FRCP, from the academic urology unit and Institute for Cancer Studies at the University of Sheffield, United Kingdom, told Medscape Medical News. "If tablets don't work, we consider options like injections and pumps, which are much less palatable for the patient and his partner."

The potential appeal of shock wave therapy is that, unlike current ED treatments, which are symptomatic and used on an on-demand basis, shock wave therapy aims to provide sustained improvement of the erectile mechanism and cure ED, he said. "Shock wave therapy potentially allows a man to return to a more normal environment, where he doesn't have to use medication. If he does still use medication, he will likely get a better result from it."

The study was partially supported by an unrestricted grant from Medispec, the company that manufactures the ED1000 device that was used in the study. Dr. Vardi and Dr. Catto have disclosed no relevant financial relationships.

ventura
Posts: 100
Joined: Mon Oct 10, 2011 12:07 pm

Re: New Treatment???

Postby ventura » Fri Jan 10, 2014 11:59 am

Sounds interesting. But i basically had nerve damage do to my Prostate surgery. Please keep us posted Philly on what you find out.
Inplanted 12-28-21 USC Doctor Loh-Doyle AMS700 with MS Pump

hoosierphilly
Posts: 132
Joined: Mon Mar 14, 2011 11:08 am

Re: New Treatment???

Postby hoosierphilly » Tue Jan 14, 2014 12:49 am

Medispec

Erectile Dysfunction – ED1000

FEEL LIKE YOU ARE 21 AGAIN

Drug-Free Solution for Erectile Dysfunction

With over 50% of men suffering from Erectile Dysfunction, the ED1000 is the most effective solution on the market. This breakthrough, therapeutic treatment, brings long lasting improvement for erectile function and sexual health to millions of men – without pain or medication.
•Significant improvement in sexual performance
•Triggers the body’s natural repair mechanism
•Enables natural erection mechanism

FAQ
Is the treatment effective?
Is it safe? Are there side-effects?
Is it painful? Are sedation or pre-treatment procedures required? What does it feel like?
Where is the treatment performed? Is it done discreetly? Is hospitalization required?


Google Medispec and help with the research plse
Medispec LTD Corporate Headquarters:

203 Perry Pkwy, Suite # 6 Gaithersburg, MD 20877-2169 USA



How long does it take?
How soon can improvement be noticed? How long will it last?
Will treatments need to be repeated in the future?
how does the technology work?
Erectile Dysfunction – ED1000
67 Year-old male overcame erectile dysfunction
A FIT 67 YEAR-OLD MALE PRESENTED COMPLAINING OF EIGHT YEARS OF PERSISTENT ED
Patient Description:
Patient was unresponsive to or dissatisfied with various PDE5i drugs, including Cialis and Viagra. He reported deteriorating marital well-being and increasing frustration and anxiety.
Treatment Description:
Since the patient was a long-term sufferer of ED who had previously undergone treatment with PDE5i drugs, his urologist, Dr. Rokkas, elected to pursue Erectile Dysfunction Shock Wave Therapy (EDSWT) using the ED1000. This treatment utilizes low-intensity extracorporeal shock waves to encourage neovascularization in the penis shaft and crus in order to relieve vascular deficiency. “This course of therapy offers multiple advantages to patient and doctor alike,” noted Dr. Rokkas. “It’s an easy-to-use, non-invasive, and pain-free process that can produce permanent improvement. Plus there is no danger of drug interaction.” Dr. Rokkas carried out the treatments, without sedation, in his clinic
solution:
The patient underwent a series of twelve treatments over a period of several weeks. After six treatments, Dr. Rokkas reported the patient experiencing morning erections. Further treatments resulting in continuing improvements: He cited that after the treatments with the ED1000, the patient was able to experience stronger erections, and in the Erection Hardness Questionnaire, he progressed from level 1 to level 3. “The patient reported no adverse effects,” noted Dr. Rokkas, “which is typically the case with EDSWT.”

anginaESMR Treatment for Recurrent Angina

62 YEAR-OLD MALE EFFECTIVELY TREATED FOR RECURRENT ANGINA WITH ESMR

Patient is an active 62-year-old male who has elevated cholesterol and suffers from diabetes.

Patient experienced sudden onset of recurrent angina at low work thresholds, along with breathlessness and dizziness. Previously he underwent several coronary bypass surgeries, which resulted in only partial revascularization. Currently, ischemic territories are unapproachable by angioplasty.



Since angioplasty was not a viable option, the patient underwent a non-invasive Extracorporeal Shockwave Myocardial Revascularization (ESMR) therapy at the University of Malaya Medical Center (UMMC), under care of Prof. Wan Azman Wan Ahmad , head of the cardiology division at UMMC. Prof. Wan Azman: “This patient has been through several coronary bypass procedures and multiple percutaneous coronary interventions. His surgical and interventional options have been exhausted, so classic therapy remains limited to the use of multiple anti-anginal medications, reduced activity, exertion, and stress level, and significant alteration and limitation of lifestyle, all of which are unacceptable to the patient. At this point in time, the only effective remaining procedure is ESMR.”

ESMR therapeutically induces the growth and development of new vasculature in zones of severe ischemia in the myocardium. The patient underwent nine ESMR sessions, during each of which he received 500 shockwave impulses precisely targeted to the ischemic area. “As a result of the therapy,” notes Prof. Wan Azman, “new capillaries and arterioles generated will connect to remnant existing vasculature, precluding the need of further intervention.”



Although results are typically evident after one month of the treatment, this patient noted an improvement in stamina after the first session. Upon receiving six treatments, there was a notable improvement in his appetite, comfort, and sense of well-being. “Before the treatment, I had given up the thought of lifting my grandchildren into my arms or getting back to my beloved gardening. Now I feel like I’ve been blessed with a new life.”



Viagra was prescribed in conjunction with EDSWT treatment. After ten treatments, the patient reported satisfying sexual relations: “My marital life is already better. I can perform sexually and I feel that I’m once again in control. The anxiety I faced for eight years is diminishing.”

ventura
Posts: 100
Joined: Mon Oct 10, 2011 12:07 pm

Re: New Treatment???

Postby ventura » Tue Jan 14, 2014 11:32 am

This treatment is not being done in the USA. Is there places in the USA that is doing trials?
Inplanted 12-28-21 USC Doctor Loh-Doyle AMS700 with MS Pump

hoosierphilly
Posts: 132
Joined: Mon Mar 14, 2011 11:08 am

Re: New Treatment???

Postby hoosierphilly » Sun Feb 02, 2014 1:45 pm

Just started the alphi-stim since I initiated this topic (which we had for other reasons ie back pain, anti-depressant on the ear lopes, anti anxiety on ear lobes etc oh and healing is faster probably due to increased blood flow (try after surgery of many kinds).

A. in New York you need a script from a nurse, psychologist, MD, or chiropractor if I remember correctly. Then you get into they want to make money.

B. my wife applies it to the base of the penis (the 4 pad part) upper and lower left and right criss crossing the currents....hoping it hits the arteries better there. My organ feels more sensitive during a 20-30 minute treatment and enjoys being played with. He will more easily get an erection and keep it while being toyed. .(not necessary for a treatment but its a nice extension of treatment). Today we put a ring on when the erection seriously began (which is does not always do). After becoming stimulated orally and fully engorged and enjoying that experience I proceeded to penetrate her and make her orgasm. I did not until she orally and manually stimulated me to orgasm. This was our first full experience during a treatment. I have done 6 now I think. Earlier in the week I found it easier to orgasm ( e-treatment early in the day and mutual sex bedtime (not intercourse) and did so without pain. Oh and I take daily Cialis 5mg. And today I did not take my low level blood pressure pill ( I take 1/2 of one, my blood pressure is not very high anyway....boarder line). My wife monitors my blood pressure at home to be sure.....so they cannot over prescribe for me. MD's only have so much time and its going to get worse with reimbursement cost.

Probably 2/3 of my prostrate has been removed by laser in a second removal 4 months ago, and I have recently complete bladder chemo and just scoped 4 days ago for cancel cells . All looks clean except MD gave me more antibiotics as didn't like the way prostate was healing. Also he finally has said the pain I have begun to have when erect on the upper outer part of penis was from the prostrate and I need to ejaculate more to eliminate that . Bet its because the nerves and blood flow is better and I bet the alphi-stim has helped that....so treatments will go on. Oh and I take daily Cialis 5mg. And today. Certainly less painful than a pump, and I believe less potential complications.

Oh and it was McCullough at NYU that I saw a couple of times unfortunately not approved in Oxford's network and expensive, he researched Viagra I believe. He may have moved or retired. (Many excellent MD's I know in Metro NY plan to retire if the reimbursements get impossible, and my wife researches for the best in all fields through more than reviews and this is difficult to learn.)
I also hope to know when relflexonic.com gets approved that I have written about and is in for FDA approval by a Maryland company. It may have better features. But bet they will target the urologists or get therapists to target them (but therapists run the risk of morals critiques)...I would buy the dam thing.

Will update you.
hoosierphilly Posts: 57Joined: Mon Mar 14, 2011 11:08 am




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Flavio
Posts: 890
Joined: Wed May 19, 2010 4:56 am

Re: New Treatment???

Postby Flavio » Sun Feb 02, 2014 5:47 pm

Yes, I've heard about this treatment and it shows great promise.

I have no idea if there are any plans to get this approved by the FDA and marketed in Europe and the US.

You mentioned the alphi-stim, what is that exactly?
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

hoosierphilly
Posts: 132
Joined: Mon Mar 14, 2011 11:08 am

Re: New Treatment???

Postby hoosierphilly » Wed Feb 05, 2014 12:50 pm

Canada supposedly has approved it, but no references yet. It is suppose to be used in Europe. We own the alpi-stim.....so experimenting on our own (we have had it a number of years for other purposes. Its a very low level Electrical treatment that you can adjust to your comfort level. Improves blood flow wherever and and improves feel good hormones when used on the ears. Currently used for anxiety, depression, addictions, and healing more effectively...depending on application point. FDA approved for that. We can say whatever we want I believe, as its not our financial or legal responsibility.

36rascal
Posts: 1
Joined: Mon Aug 05, 2013 2:01 pm

Re: New Treatment???

Postby 36rascal » Thu Feb 06, 2014 3:19 pm

It would seem important to point out that the shock treartment done with success in Israel is NOT the same shock treatment provided by TENS and other electric shock devices. Alpha stim appears to be in the same family as TENS.
The Isreal research used an acoustic shock device patterned after acoustic shock machines that are used to break up kidney stones and apparently does not provide electric shock to tissues, so that's where confusion arises.
Electro stim is apparently being used successfully for individual encounters. However in searching I've not seen proof that it helps with ED over the long term, it has to be used each time.
If someone has cured ED or has greatly improved the condition longterm using a TENS or similar device, please tell us the settings used to achieve this!
36 Rascal.

hoosierphilly
Posts: 132
Joined: Mon Mar 14, 2011 11:08 am

Re: New Treatment???

Postby hoosierphilly » Tue Feb 11, 2014 12:32 pm

Individual responses means what? If it is temporary, it might be as or more effective than Viagara or Celias....and in the end more economical.......It might open up the pathways better as well. If you don't sustain an erection try a good ring in a timely fashion simultaneously.


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