How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Anything goes when it comes to ED.

For how long have you been using/have used PDE5s?

<1 year
9
15%
1-3 years
11
19%
3-5 years
5
8%
5-8 years
3
5%
8-10 years
11
19%
10-15 years
9
15%
>15 years
11
19%
 
Total votes: 59

steamfitter
Posts: 56
Joined: Mon May 31, 2021 10:47 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby steamfitter » Sun Nov 14, 2021 12:51 pm

Simbarn wrote:The healthier and fitter you are, the greater the chance they will work longer.


I am hoping so. At 38, I am in the gym 4-6 hours a week. I eat very lean, low-sugar, low fat. Don't drink alcohol, let alone smoke. I am in very good shape, better than any guy I know my age (6-pack abs and everything). I barely even eat the foods I used to love like pizza and ice cream. The only thing I haven't done is gone keto or raw vegan, I don't think I could do my job if I cut out carbs or meat completely. I have heard on the internet that those diets are supposed to reset your body and cure ED, but I'm pretty skeptical.

EveningWood wrote:P.S. Regarding your recommendations - I fully agree. It is sad however, if you have been living your life healthy and exercised, and still have severe ED.


I was the poster boy for healthy living, didn't drink, didn't smoke, in good shape. But a millennial woman doctor put me on a medication I should never have been on (and she is convinced has nothing to do with my chronic ED that I've suffered ever since), and here I am on this website after 4 years of fighting this battle. Life is not fair though, and ED is only as big of a deal as you make it. Staying positive, and focusing on the solutions is the only way to survive this condition.

I'm not giving up hope. I focus all my energy on making money, being in great shape, taking whatever drug or treatment that I have to in order to feel human again. I'm not going to let my medical problems make me give up hope, I will keep fighting until the end.

EveningWood
Posts: 45
Joined: Sat Jun 19, 2021 3:12 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby EveningWood » Wed Nov 17, 2021 3:45 pm

bldoink wrote:I strongly agree with the "Use it or Lose it." statement. It needs to get erect regularly by some method.



Hi bldoink and Benjohn,


Thanks for sharing this, I actually never did know or read this anywhere before this site.
Seems that I would need to take action.


Best regards,
EveningWood

Simbarn
Posts: 358
Joined: Tue Mar 10, 2020 8:08 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby Simbarn » Wed Nov 17, 2021 6:01 pm

steamfitter wrote:
Simbarn wrote:The healthier and fitter you are, the greater the chance they will work longer.


I am hoping so. At 38, I am in the gym 4-6 hours a week. I eat very lean, low-sugar, low fat. Don't drink alcohol, let alone smoke. I am in very good shape, better than any guy I know my age (6-pack abs and everything). I barely even eat the foods I used to love like pizza and ice cream. The only thing I haven't done is gone keto or raw vegan, I don't think I could do my job if I cut out carbs or meat completely. I have heard on the internet that those diets are supposed to reset your body and cure ED, but I'm pretty skeptical.

EveningWood wrote:P.S. Regarding your recommendations - I fully agree. It is sad however, if you have been living your life healthy and exercised, and still have severe ED.


I was the poster boy for healthy living, didn't drink, didn't smoke, in good shape. But a millennial woman doctor put me on a medication I should never have been on (and she is convinced has nothing to do with my chronic ED that I've suffered ever since), and here I am on this website after 4 years of fighting this battle. Life is not fair though, and ED is only as big of a deal as you make it. Staying positive, and focusing on the solutions is the only way to survive this condition.

I'm not giving up hope. I focus all my energy on making money, being in great shape, taking whatever drug or treatment that I have to in order to feel human again. I'm not going to let my medical problems make me give up hope, I will keep fighting until the end.


What was the drug that you took and then ED followed?
Age 57, ED issues for 15-20 years. Testosterone replacement with Enanthate and Ovidrel. Currently using generic Tadalafil 2.5mgs and Resveratrol daily.

steamfitter
Posts: 56
Joined: Mon May 31, 2021 10:47 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby steamfitter » Fri Nov 19, 2021 6:25 pm

Simbarn wrote:
steamfitter wrote:
Simbarn wrote:The healthier and fitter you are, the greater the chance they will work longer.


I am hoping so. At 38, I am in the gym 4-6 hours a week. I eat very lean, low-sugar, low fat. Don't drink alcohol, let alone smoke. I am in very good shape, better than any guy I know my age (6-pack abs and everything). I barely even eat the foods I used to love like pizza and ice cream. The only thing I haven't done is gone keto or raw vegan, I don't think I could do my job if I cut out carbs or meat completely. I have heard on the internet that those diets are supposed to reset your body and cure ED, but I'm pretty skeptical.

EveningWood wrote:P.S. Regarding your recommendations - I fully agree. It is sad however, if you have been living your life healthy and exercised, and still have severe ED.


I was the poster boy for healthy living, didn't drink, didn't smoke, in good shape. But a millennial woman doctor put me on a medication I should never have been on (and she is convinced has nothing to do with my chronic ED that I've suffered ever since), and here I am on this website after 4 years of fighting this battle. Life is not fair though, and ED is only as big of a deal as you make it. Staying positive, and focusing on the solutions is the only way to survive this condition.

I'm not giving up hope. I focus all my energy on making money, being in great shape, taking whatever drug or treatment that I have to in order to feel human again. I'm not going to let my medical problems make me give up hope, I will keep fighting until the end.


What was the drug that you took and then ED followed?

Accutane.

Simbarn
Posts: 358
Joined: Tue Mar 10, 2020 8:08 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby Simbarn » Sun Nov 21, 2021 5:29 pm

steamfitter wrote:I was the poster boy for healthy living, didn't drink, didn't smoke, in good shape. But a millennial woman doctor put me on a medication I should never have been on (and she is convinced has nothing to do with my chronic ED that I've suffered ever since), and here I am on this website after 4 years of fighting this battle. Life is not fair though, and ED is only as big of a deal as you make it. Staying positive, and focusing on the solutions is the only way to survive this condition.


There is quite an amount of evidence now to suggest that isotretinoin (Roaccutane) can or is causing long lasting sexual function dysfunctions for a small percentage of males. I do not think she can be "convinced" at all that it may not be responsible. I knew someone that also had this issue from Roaccutane. They also had the mental side effects such as an anhedonia type of depression after the use of this drug.

5 alpha reductase drugs used for hair-loss are another medication causing substantial sexual issues in a percentage of men. Science is now discovering why Finasteride causes this to occur, so hopefully it will be banned for cosmetic use soon. I do not think they have found why isotretinoin does this yet other than interfering with testosterone production?
Age 57, ED issues for 15-20 years. Testosterone replacement with Enanthate and Ovidrel. Currently using generic Tadalafil 2.5mgs and Resveratrol daily.

steamfitter
Posts: 56
Joined: Mon May 31, 2021 10:47 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby steamfitter » Sun Nov 21, 2021 7:25 pm

Simbarn wrote:
steamfitter wrote:I was the poster boy for healthy living, didn't drink, didn't smoke, in good shape. But a millennial woman doctor put me on a medication I should never have been on (and she is convinced has nothing to do with my chronic ED that I've suffered ever since), and here I am on this website after 4 years of fighting this battle. Life is not fair though, and ED is only as big of a deal as you make it. Staying positive, and focusing on the solutions is the only way to survive this condition.


There is quite an amount of evidence now to suggest that isotretinoin (Roaccutane) can or is causing long lasting sexual function dysfunctions for a small percentage of males. I do not think she can be "convinced" at all that it may not be responsible. I knew someone that also had this issue from Roaccutane. They also had the mental side effects such as an anhedonia type of depression after the use of this drug.

5 alpha reductase drugs used for hair-loss are another medication causing substantial sexual issues in a percentage of men. Science is now discovering why Finasteride causes this to occur, so hopefully it will be banned for cosmetic use soon. I do not think they have found why isotretinoin does this yet other than interfering with testosterone production?

Yes, that is exactly what happened to me. Since I first took Accutane, there has been a lot more media attention to this issue. I can't imagine a doctor doing all those years of schooling who can't do a simple google search and discovering all of this. I had my T levels checked, they said I was on the high side. There is more to it that that, I am sure. You can have high T levels, but that doesn't mean your body is effectively utilizing it. There are other guys here who are suffering post-Accutane and post-Finasteride too. Part of me wishes that every guy who takes these drugs would become impotent, maybe then the doctors would acknowledge the truth and these poisons would finally get taken off the market for good.

Cozpgh
Posts: 26
Joined: Tue Nov 23, 2021 6:32 am

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby Cozpgh » Tue Nov 30, 2021 1:10 am

I started taking Viagra in 1999 - pretty much right when it came out. I was 25 years old and had been experiencing erectile dysfunction since becoming sexually active in my teens. 25mg of Viagra about 15 minutes to a half hour before sex would result in an instant facial flush, stuffed up nose, and long lasting spontaneous erections even with no or just mild stimulation. A hot and heavy makeout session would usually result in me being erect in my pants and pulling out a very hard ready to go dick.

Sometimes my sex was more porn star performance than others but I had more successes than failures on just that 25mg dose of Viagra for about 18 years. Even when I'd cut up a 100mg tablet, splitting into four's since the pills were much more expensive then before generics hit the U.S. market, I'd get the facial flush and a spontaneous erection from just a lick of some of the crushed pill powder in the cutter.

Maybe 15 years in, I started to notice more stimulation being needed before I'd be hard. Or I'd have to masturbate myself while going down on my wife to be ready for penetration. I figured it was just married sex life. Lack of that early passion. Somewhat monotonous. Relationship problems. Job stresses. Life.

A lot of it was that. Our marriage ended. It was then when I discovered that the once predictable 25mg of Viagra was completely failing me with new partners. Sometimes to the point of not getting an erection at all which was a new experience for me. My problem, even going back to my teens, was I'd be very hard for a long time and my erection would gradually go down as I leaked more precum or when I was close to ejaculating but couldn't. I went up to 50mg and was having penetrative sex but still losing my erection off an on through a 1 to 2 hour session. Just up and down. Thankfully my partner then - who has become my girlfriend was just amazed a man wanted to be in bed pleasing her for that long and never made a big deal about my constant in and out and up and down. Thankfully, for me and I guess my partners, all those years of ED going back to my teens has made me a better lover in all the other pleasing ways to get them to look past my finicky dick. She saw the 6 minutes of fucking, 15 minutes of oral and hands, 10 more minutes of fucking, kissing and making out, on and on and on to be satisfying. I on the other hand was frustrated.

She is 17 years younger than me, polyamorous, and ethically nonmonogamous. A girlfriend of hers was brought into our relationship. Every man's dream, right? The first time we all got together, I failed on 100mg of Viagra and 20mg of Cialis earlier in the day. In addition to taking L Arginine and Citrulline and also going on TRT. I've since experimented with varying dosages of single and combined PDE5 inhibitors, PT 141, apomorphine, oxytocin, and was even talked into Gainswave and a P Shot by my TRT doctor which didn't make much of a difference besides adding some girth and veins. My girlfriend is still very satisfied with our sex life and we've had some amazing experiences together even with my inconsistent erections. She knows how much it frustrates me and how much its added to my already bad performance anxiety. She can tell when I'm hesitant to play with her or for us to play with anyone else together because I'm worried about my erection quality and performance.

My most consistent success has been 5 mg of Tadalafil (Cialis) daily, an as need dosage of Sildenafil (Viagra) up to 150mg or 200mg, and some PT 141 earlier in the day. The strangest thing about the Sildenafil/Viagra is I no longer have any physical side effect from the drug whatsoever. Even in high dosages or repeating a 25mg to 100mg dose every 4 to 6 hours for a 24 hour period. No facial flush. No stuffed up nose. Nothing visual or hearing issues, which is good. No headaches or dizziness. Just some occasional acid reflux on days where I'm dosing every 4 to 6 hours. Granted, I've never done anything higher than a 200mg dose of Sildenafil at once, you'd think with the combined PDE5s, the arginine/citrulline, etc. I'd have some sort of physical discomfort or adverse reaction. Especially considering how red my face used to get from just that 25mg (and sometimes smaller) dose back in the day. I sometimes think that reaction to Viagra/Sildenafil ended when I started taking the Citrulline/Arginine supplement but I've since tried removing that from my regimen and that specific medication reaction never returned.

I've read where you don't build up a tolerance to these drugs - your underlying condition worsens - but how have I've gone from multiple adverse reactions/side effects to nothing even on higher or more steady/consistent doses? My heart workup was fine. Blood panels the past five years have been good. I'm a runner. My BP is always a bit high at first at the doctor's office but my doctor knows to keep checking it the more we talk through the appointment and it always falls down to a normal range and is normal when I check it at home even if pulling out the cuff alone is sometimes enough to make it temporarily spike. It comes down on its own after I relax. It's also never been dangerously low on the combined or high dose PDE5's. The bottom number has gotten into the 60s here and there but with no side effects. The white coat syndrome I have initially at the doctor's office does make me wonder if my body reacts to sexual situations the the same way I react when I first get to the doctors. That adrenaline spike and temporary BP spike negatively affecting my erections. Maybe the light Viagra dosage coupled with the predictability and comfortability of married sex was enough to remove my sexual performance anxieties from the equation. It's weird because I was ultimately in bad marriage but the 2 day a week sex on Wednesdays and Sundays quieted my performance anxiety - especially knowing a 25mg dose of Viagra was there to help me out. And, just like when my BP goes down the more comfortable I get talking to my doctor, maybe those times I feel like the oral meds work for me today are really just times I'm able to get into a relaxed state. Not necessarily the higher doses of meds. We've had great sex and I've had a better erection sometimes 6 to 8 hours after I've taken a Viagra dosage when I wasn't having a good erection when we initially tried an hour or so from when I dosed. It seems like the PDE5 inhibitors are still working for me but are just being metabolized differently to the point where I don't feel the side effects I used to feel that indicated to me I was ready to go - like the facial flushing - anymore.

And I'm still having sex 5 to 10 times a week - in fact, the best sex of my life - just with inconsistent up and down erections. I really feel like I shouldn't complain but I'm so consumed by all of this and it's so distracting. Especially since me and my girlfriend enjoy playing with others together. I don't want to avoid those situations because I'm worried about my ED.

I opened up to my girlfriend the other night about Trimix injections and a possible implant down the road. She wasn't as freaked out by either as I thought she'd be. I explained some of the things I've learned from discussions here. Even showed her a few pics and videos of implants. We were laughing about all the possibilities of us going to sex clubs with my pumped up dick. She feels I'm overreacting and probably don't need to inject or gut my penis just yet, however, she also doesn't want me going down this slippery slope where I'm just combining and upping the oral medications to higher and higher dosages to the point it does become dangerous. Even though, so far, I'm lucky and have had no real side effects on these current combinations and high doses.

I tried to get an appointment with my urologist for a doppler/ultrasound and test injection but he couldn't see me until February. So I went through Olympia and a telemedicine appointment for a Trimix vial with antidote. Have stopped the daily Cialis/Tadalafil and supplementation for a few days. It'll be a bit weird trying to have sex without a PDE5 inhibitor for the first time in 22 years and I'm hoping I've studied up enough on injection technique. I've also considered still taking a 25mg or 50mg dose of Sildenafil and going lighter than the 10 units suggested for my first dose - like 3 or 5 units. I'm not necessarily looking for 2 hour sex here every time. I just want to be able to have intercourse to completion without losing and regaining my erection multiple times and maybe a light dose of the Trimix coupled with the dosage of Sildenafil that worked for me multiple times a week from 1999 to 2017 will be enough to carry me through or at least have a renewed confidence going into the encounter. I'm sure I'll talk about my experiences here. This is my first post hence the length. But, to answer your question, I got about 15 to 20 years out of my use and it could be argued they're still somewhat effective for me since I'm sexually active despite my frustrations.
48 years old, ED since teens, 25-50mg of Sildenafil worked for 20 years but now require 100-200mg of Sildenafil - sometimes split into 25-50mg every 4 hours - + daily Tadalafil at 5-20mg. Have had P Shot, Gainswave, TRT, and now on to Trimix injections.

steamfitter
Posts: 56
Joined: Mon May 31, 2021 10:47 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby steamfitter » Tue Nov 30, 2021 9:56 pm

Cozpgh wrote:I started taking Viagra in 1999 - pretty much right when it came out. I was 25 years old and had been experiencing erectile dysfunction since becoming sexually active in my teens. 25mg of Viagra about 15 minutes to a half hour before sex would result in an instant facial flush, stuffed up nose, and long lasting spontaneous erections even with no or just mild stimulation. A hot and heavy makeout session would usually result in me being erect in my pants and pulling out a very hard ready to go dick.

Sometimes my sex was more porn star performance than others but I had more successes than failures on just that 25mg dose of Viagra for about 18 years. Even when I'd cut up a 100mg tablet, splitting into four's since the pills were much more expensive then before generics hit the U.S. market, I'd get the facial flush and a spontaneous erection from just a lick of some of the crushed pill powder in the cutter.

Maybe 15 years in, I started to notice more stimulation being needed before I'd be hard. Or I'd have to masturbate myself while going down on my wife to be ready for penetration. I figured it was just married sex life. Lack of that early passion. Somewhat monotonous. Relationship problems. Job stresses. Life.

A lot of it was that. Our marriage ended. It was then when I discovered that the once predictable 25mg of Viagra was completely failing me with new partners. Sometimes to the point of not getting an erection at all which was a new experience for me. My problem, even going back to my teens, was I'd be very hard for a long time and my erection would gradually go down as I leaked more precum or when I was close to ejaculating but couldn't. I went up to 50mg and was having penetrative sex but still losing my erection off an on through a 1 to 2 hour session. Just up and down. Thankfully my partner then - who has become my girlfriend was just amazed a man wanted to be in bed pleasing her for that long and never made a big deal about my constant in and out and up and down. Thankfully, for me and I guess my partners, all those years of ED going back to my teens has made me a better lover in all the other pleasing ways to get them to look past my finicky dick. She saw the 6 minutes of fucking, 15 minutes of oral and hands, 10 more minutes of fucking, kissing and making out, on and on and on to be satisfying. I on the other hand was frustrated.

She is 17 years younger than me, polyamorous, and ethically nonmonogamous. A girlfriend of hers was brought into our relationship. Every man's dream, right? The first time we all got together, I failed on 100mg of Viagra and 20mg of Cialis earlier in the day. In addition to taking L Arginine and Citrulline and also going on TRT. I've since experimented with varying dosages of single and combined PDE5 inhibitors, PT 141, apomorphine, oxytocin, and was even talked into Gainswave and a P Shot by my TRT doctor which didn't make much of a difference besides adding some girth and veins. My girlfriend is still very satisfied with our sex life and we've had some amazing experiences together even with my inconsistent erections. She knows how much it frustrates me and how much its added to my already bad performance anxiety. She can tell when I'm hesitant to play with her or for us to play with anyone else together because I'm worried about my erection quality and performance.

My most consistent success has been 5 mg of Tadalafil (Cialis) daily, an as need dosage of Sildenafil (Viagra) up to 150mg or 200mg, and some PT 141 earlier in the day. The strangest thing about the Sildenafil/Viagra is I no longer have any physical side effect from the drug whatsoever. Even in high dosages or repeating a 25mg to 100mg dose every 4 to 6 hours for a 24 hour period. No facial flush. No stuffed up nose. Nothing visual or hearing issues, which is good. No headaches or dizziness. Just some occasional acid reflux on days where I'm dosing every 4 to 6 hours. Granted, I've never done anything higher than a 200mg dose of Sildenafil at once, you'd think with the combined PDE5s, the arginine/citrulline, etc. I'd have some sort of physical discomfort or adverse reaction. Especially considering how red my face used to get from just that 25mg (and sometimes smaller) dose back in the day. I sometimes think that reaction to Viagra/Sildenafil ended when I started taking the Citrulline/Arginine supplement but I've since tried removing that from my regimen and that specific medication reaction never returned.

I've read where you don't build up a tolerance to these drugs - your underlying condition worsens - but how have I've gone from multiple adverse reactions/side effects to nothing even on higher or more steady/consistent doses? My heart workup was fine. Blood panels the past five years have been good. I'm a runner. My BP is always a bit high at first at the doctor's office but my doctor knows to keep checking it the more we talk through the appointment and it always falls down to a normal range and is normal when I check it at home even if pulling out the cuff alone is sometimes enough to make it temporarily spike. It comes down on its own after I relax. It's also never been dangerously low on the combined or high dose PDE5's. The bottom number has gotten into the 60s here and there but with no side effects. The white coat syndrome I have initially at the doctor's office does make me wonder if my body reacts to sexual situations the the same way I react when I first get to the doctors. That adrenaline spike and temporary BP spike negatively affecting my erections. Maybe the light Viagra dosage coupled with the predictability and comfortability of married sex was enough to remove my sexual performance anxieties from the equation. It's weird because I was ultimately in bad marriage but the 2 day a week sex on Wednesdays and Sundays quieted my performance anxiety - especially knowing a 25mg dose of Viagra was there to help me out. And, just like when my BP goes down the more comfortable I get talking to my doctor, maybe those times I feel like the oral meds work for me today are really just times I'm able to get into a relaxed state. Not necessarily the higher doses of meds. We've had great sex and I've had a better erection sometimes 6 to 8 hours after I've taken a Viagra dosage when I wasn't having a good erection when we initially tried an hour or so from when I dosed. It seems like the PDE5 inhibitors are still working for me but are just being metabolized differently to the point where I don't feel the side effects I used to feel that indicated to me I was ready to go - like the facial flushing - anymore.

And I'm still having sex 5 to 10 times a week - in fact, the best sex of my life - just with inconsistent up and down erections. I really feel like I shouldn't complain but I'm so consumed by all of this and it's so distracting. Especially since me and my girlfriend enjoy playing with others together. I don't want to avoid those situations because I'm worried about my ED.

I opened up to my girlfriend the other night about Trimix injections and a possible implant down the road. She wasn't as freaked out by either as I thought she'd be. I explained some of the things I've learned from discussions here. Even showed her a few pics and videos of implants. We were laughing about all the possibilities of us going to sex clubs with my pumped up dick. She feels I'm overreacting and probably don't need to inject or gut my penis just yet, however, she also doesn't want me going down this slippery slope where I'm just combining and upping the oral medications to higher and higher dosages to the point it does become dangerous. Even though, so far, I'm lucky and have had no real side effects on these current combinations and high doses.

I tried to get an appointment with my urologist for a doppler/ultrasound and test injection but he couldn't see me until February. So I went through Olympia and a telemedicine appointment for a Trimix vial with antidote. Have stopped the daily Cialis/Tadalafil and supplementation for a few days. It'll be a bit weird trying to have sex without a PDE5 inhibitor for the first time in 22 years and I'm hoping I've studied up enough on injection technique. I've also considered still taking a 25mg or 50mg dose of Sildenafil and going lighter than the 10 units suggested for my first dose - like 3 or 5 units. I'm not necessarily looking for 2 hour sex here every time. I just want to be able to have intercourse to completion without losing and regaining my erection multiple times and maybe a light dose of the Trimix coupled with the dosage of Sildenafil that worked for me multiple times a week from 1999 to 2017 will be enough to carry me through or at least have a renewed confidence going into the encounter. I'm sure I'll talk about my experiences here. This is my first post hence the length. But, to answer your question, I got about 15 to 20 years out of my use and it could be argued they're still somewhat effective for me since I'm sexually active despite my frustrations.

How long were you married for? Did ED affect the courtship/marriage, or cause it to end?

Cozpgh
Posts: 26
Joined: Tue Nov 23, 2021 6:32 am

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby Cozpgh » Wed Dec 01, 2021 2:49 pm

18 year relationship and 7 year marriage. Divorce was unrelated to ED. Weren't many ED experiences during our relationship because the 25mg Viagra dose was so effective. But I absolutely needed it to perform every time. If things would start up spontaneously, I had pills in my wallet and would just excuse myself to the restroom to pop one and then give her foreplay for a half hour or 45 minutes until I felt the facial flush and knew the medicine was kicking in. Even if I lost it after going at it hard for awhile, I knew the medication would help me get it back up to finish. And I tended to get off very quickly with her because her vagina was small and super tight so it was basically 5 to 7 minutes of sex once or twice a week that entire time. She would orgasm several times and didn't want or need any marathon sessions or repeat performance. So it was one and done, short and sweet, and minimal performance anxiety. She never even had any idea I used anything at all. Some erectile issues began to occur maybe 15 years but it was mainly me realizing the 25mg dose of Viagra wasn't as reliable or effective anymore. I would only get hard with penile stimulation and would go soft before finishing at times but not get it back.
48 years old, ED since teens, 25-50mg of Sildenafil worked for 20 years but now require 100-200mg of Sildenafil - sometimes split into 25-50mg every 4 hours - + daily Tadalafil at 5-20mg. Have had P Shot, Gainswave, TRT, and now on to Trimix injections.

EveningWood
Posts: 45
Joined: Sat Jun 19, 2021 3:12 pm

Re: How long before PDE5s (Cialis, Viagra, Levitra) stop working?

Postby EveningWood » Sat Dec 25, 2021 1:10 pm

Cozpgh wrote:18 year relationship and 7 year marriage. Divorce was unrelated to ED. Weren't many ED experiences during our relationship because the 25mg Viagra dose was so effective. But I absolutely needed it to perform every time. If things would start up spontaneously, I had pills in my wallet and would just excuse myself to the restroom to pop one and then give her foreplay for a half hour or 45 minutes until I felt the facial flush and knew the medicine was kicking in. Even if I lost it after going at it hard for awhile, I knew the medication would help me get it back up to finish. And I tended to get off very quickly with her because her vagina was small and super tight so it was basically 5 to 7 minutes of sex once or twice a week that entire time. She would orgasm several times and didn't want or need any marathon sessions or repeat performance. So it was one and done, short and sweet, and minimal performance anxiety. She never even had any idea I used anything at all. Some erectile issues began to occur maybe 15 years but it was mainly me realizing the 25mg dose of Viagra wasn't as reliable or effective anymore. I would only get hard with penile stimulation and would go soft before finishing at times but not get it back.


Hi Cozpgh,

Again, thank you very much for the extensive and extremely informative (at least for me, who has not yet used PDE5s) posts.

Thus far I have been reading most of the threads since January this year. The main theme with almost all PDE5 users is that their intake is basically daily.

So for example, a person uses Cialis for 10 years and has no response to it after the tenth year. However, that is 10 years *365 pills per day = total of 3,650 pills. In theory, won't it be possible to extend the effective usage period by taking only for example one pill three times per week (without additional doses before sex, if I am receptive enough)? This would mean a total of 1,650 pills taken over the same period. Unfortunately, that would also mean to have sex less days in a week.

It would be very helpful if someone has more insight on this. It's possible that it might be just wishful thinking on my part.

Best regards,
EveningWood


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