MED3000 for ED: an update

Anything goes when it comes to ED.
Flavio
Posts: 645
Joined: Wed May 19, 2010 4:56 am

Re: MED3000 for ED: an update

Postby Flavio » Fri Apr 16, 2021 3:24 pm

Mazzio wrote:The product should be available during this year.


Let's hope so!

I've had zero results with topical treatments (Vitaros, Scream Cream, Libido Cream), maybe this one will work better.
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

Flavio
Posts: 645
Joined: Wed May 19, 2010 4:56 am

Re: MED3000 for ED: an update

Postby Flavio » Fri Apr 16, 2021 3:41 pm

In the US, it seems that the small confirmatory clinical study - FM71 - should start in the second half of this year.

In Europe, confirmation of approval should be issued by the end of May.

More on this:

https://www.thetimes.co.uk/article/futu ... -lrqd3llp0

https://www.sharecast.com/news/news-and ... 47916.html

This article speaks of development and commercialisation of MED3000 in China and South East Asia:

https://www.proactiveinvestors.co.uk/co ... 46527.html
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

confused95
Posts: 74
Joined: Tue Mar 23, 2021 4:25 am

Re: MED3000 for ED: an update

Postby confused95 » Thu May 20, 2021 1:57 pm

Do you think this will work even without sexual stimulation?
25yo from Italy. Psychogenic ed since dec 2019, got worse in Jan 2021 (can hardly masturbate but I still have some super hard morning woods and crazy spontaneous erections). On antidepressants now, working hard to get back to my heyday :(

Biker21
Posts: 8
Joined: Mon May 10, 2021 4:23 pm

Re: MED3000 for ED: an update

Postby Biker21 » Fri May 21, 2021 9:22 am

Like the others have said, it would great if it worked but as someone who works in science the mode of action is a bit shaky.

Evaporative process, that could be it contains a solvent that evaporates near body temperature. Solvent can be any liquid that solutes can dissolve into, e.g waters a good solvent.
It might work as it creates a sensation (colder) when it evaporates - who knows?

I do know I'll give it a go as I'm happy to try anything to get it to work!

I like the final line -
But I do know one truth - whoever it was at Futura who came up with the idea of marketing the placebo deserves an award for sheer chutzpah.

https://www.discovermagazine.com/health/the-erection-of-a-placebo
47yrs old. Lifetime ED sufferer
PDE5's, VED, Mild/stable Pyronies

Simbarn
Posts: 256
Joined: Tue Mar 10, 2020 8:08 pm

Re: MED3000 for ED: an update

Postby Simbarn » Thu May 27, 2021 6:38 pm

Biker21 wrote:
I like the final line -
But I do know one truth - whoever it was at Futura who came up with the idea of marketing the placebo deserves an award for sheer chutzpah.

https://www.discovermagazine.com/health/the-erection-of-a-placebo


I like that last line too!

Futura medical states that their product is working on nerves in the head of the penis..

Let’s take a look at what this preparation may actually be stimulating. The head or glans of the penis is full of sensory somatic neurons. They are called afferent neurons that send signals back towards the body. All of these sensory signals travel via the dorsal nerve, which then becomes the all-important pudendal nerve. This nerve and the signals that it sends back and forth are responsible for reflexogenic erections. It is also responsible for the feelings of sexual pleasure we feel in the head of the penis and the scrotum.

What is a reflexogenic erection or as it is also called a reflex erection? It is an erection that is stimulated by touch to these nerves which are in great abundance in the glans. They are also in greater amounts in the foreskin and under the lip of the glans, especially in the area underneath where the foreskin joins the glans (this area is negatively affected when men are circumcised, depending on the skill of the doctor doing it, one of the reasons I would never have a child of mine circumcised unless it was necessary). We all know how sexually sensitive this area is!
These nerves send an afferent signal that travels back to the spinal cord erection centre in the sacral area, S2-S4. A signal is then sent back to the penis directly (without any signal from the brain) which then travels through another route directly into the corpus cavernosum stimulating the erectile process (promoting the release of NO) which has the end result of relaxing smooth muscle. Therefore these erections happen only from sensory input from these neurons in the glans or elsewhere in the genital region. They are not generated by signals sent from the brain, it is a reflex action. Psychogenic erections are another part of the erectile process. These are generated by our mental thoughts, visual and olfactory(smell) stimuli. Signals are sent from our central nervous system via the parasympathetic route directly into the centre of the erectile tissues. These strong signals also effect the relaxation of smooth muscle. It is a COMBINATION of the TWO neural signals the generate strong lasting erections. If one of these two neural systems is not working efficiently erections can either not last or not be firm enough for penetration.
Reflex erections are more responsible for the generation of a strong and firm erection (owing to sensation, reflex signal and stimulus of two specific pelvic floor muscles), whereas psychogenic erections seem to maintain the duration of an erection (that is when mechanical stimulation of the afferent neurons in the glans stops or pauses). However, I am sure there would be some crossover. So one can see from this that both are necessary for good erectile performance.

This topical gel, may be stimulating these sensory neurons in much the same way as touch, which then causes the reflex loop to generate a reflex erection. While this may be occurring it may also encourage a placebo effect in the brain, as the male perceives that the product is generating an erection and therefore his brain sends psychogenic parasympathetic signals back to the penis via the other neural system as described above. The two part neural process kicks into action! It may be that initially this gel has a slightly more effective method of stimulating these nerves in the glans of the penis than compared to normal touch due to this evaporative process? This a big question mark!
I would ask how long could this be effective? How long could this gel stay active on the skin, does it penetrate and stay active for a reasonable period of time? Do the nerves become desensitised to this over time?
Could it be that this gel boosts the performance of this neural pathway which then helps some forms of ED?

I do think that after understanding how the neural aspect of erectile function works to some degree, that this gel could only be exerting an influence on the above mentioned neural pathway and if so its reliability would be questionable owing to the fact that the neural side of erectile function depends on both systems.

However, I also think that dysfunctions with the neurophysiology of erectile function could be underestimated. I say this because the nerve that is negatively affected with regard to pelvic floor dysfunctions is the Pudendal nerve and this can have major negative implications with regard to sexual function in the male.

Let’s wait and see!
Age 56, ED issues for 10-15 years, on T replacement. Currently using generic Tadalafil 5mgs daily.

Flavio
Posts: 645
Joined: Wed May 19, 2010 4:56 am

Re: MED3000 for ED: an update

Postby Flavio » Fri May 28, 2021 5:01 pm

An article from The Sun (19 Mar 2021) that includes images of the actual gel:

https://www.thesun.co.uk/news/14397404/ ... an-viagra/
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

Flavio
Posts: 645
Joined: Wed May 19, 2010 4:56 am

Re: MED3000 for ED: an update

Postby Flavio » Fri May 28, 2021 5:03 pm

Simbarn wrote:[...] This topical gel, may be stimulating these sensory neurons in much the same way as touch, which then causes the reflex loop to generate a reflex erection. [...]


As always, a great read.
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

User avatar
phallus
Posts: 36
Joined: Mon Jan 04, 2021 10:51 am

Re: MED3000 for ED: an update

Postby phallus » Fri May 28, 2021 7:12 pm

@simbarn

does the fm57 clinical trial results appear vague to you?

It claims MED3000 being statistically significant in each separate cohort of severity (mild, moderate and severe) and it showed meaningful clinical difference in 60% of patients.

First of, what determines if your ED is mild, moderate or severe?

secondly, "meaningful clinical difference" -> does this mean the compound created an erection good enough for penetration? How many of the 60% success group had severe ED?

"It will likely find use in the substantial number of patients, especially those with ED of a mild to moderate nature" -> considering the 60% success rate (which is that of pills), this reads like people having good effect on pde5 inhibitors would be the ones mainly benefiting from MED3000 which appear to be rather few on frank talk. I find it difficult to believe MED3000 being able to help guys needing injections to perform.
Born 1995
Severe performance anxiety, psychogenic ED my whole life.
Possibly some degree of organic ED too.
Experimenting with PGE1 injections.

Mazzio
Posts: 71
Joined: Thu Jan 07, 2016 2:58 pm

Re: MED3000 for ED: an update

Postby Mazzio » Sat May 29, 2021 8:53 am

Currently I am using a combo with sildenafil 50 mg + Caverject 20 mg.
With MED3000 I would be happy to go to the MED3000 + Caveject combo.
Or maybe MED3000 + sildenafil combo.
Or a MED3000 + sildenafil + Caverject combo.
60 yrs, had venous leak all my life, sildenafil and other pills don't work anymore properly, using Caverject, tried shockwave.

Hunchback
Posts: 267
Joined: Sun Apr 30, 2017 5:00 am

Re: MED3000 for ED: an update

Postby Hunchback » Sat May 29, 2021 9:56 am

Indeed, i was hoping this drug might be a supplement rather than a replacement. As phallus said, it seems unrealistic to believe it'll work for people that need injections. (I suppose that's considered "sever" ED?)

All the pills, gels and stuff like that seem to work for people with "mild" ED, which for me is people that don't have major physiological damage such as spinal cord injury, nerve damage because of prostate removal and other similar. If your ED is simply because of "age" or hormonal disbalance, stress or other psychological factors, it might work as a "main" treatment, but for the rest it'll probably be as good as PDE5 inhibitors.
Still, if it can replace pills while not having their annoying side effects, i will be quite happy to use it.
37 years old, married. ED all my life because of spinal cord injury caused by a tumor in early infant age. Using standard EDEX20 for ~ 16 years.


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