PT-141 (Bremelanotide)

Anything goes when it comes to ED.
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Stew52
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Re: PT-141 (Bremelanotide)

Postby Stew52 » Sat Dec 19, 2020 6:59 pm

Going back to try to optimize things. Tried 1mg and side effects were tolerable. Reaction was nice. Did in the evening, 5:30pm, for target reaction next day. Some stirrings started in 6-8 hours (11pm-1am) but hit a steep peak in 10-14 hours (3-7 am). The drop-off is kinda step and by 8-9am not much left, a bit. Wife doesn't like being awaken so need to adjust times so "peaks" coincide. Shot at midnight (don't relish that with flushing, etc) ought to put it just about right for a mid-day "hook-up" period. I've got about 11 mg left to fool around with.
Last edited by Stew52 on Mon Mar 08, 2021 8:35 pm, edited 2 times in total.
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

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Stew52
Posts: 366
Joined: Fri Apr 13, 2018 4:22 pm
Location: Central TX

Re: PT-141 (Bremelanotide)

Postby Stew52 » Wed Dec 23, 2020 8:41 pm

If no one objects, I'd propose removing all the middle posts and leave only the first and last couple to avoid all the long-post duplication in the PDF narrative I attached. I'll give this a week.
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

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Stew52
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Location: Central TX

Re: PT-141 (Bremelanotide)

Postby Stew52 » Mon Mar 08, 2021 8:34 pm

Ran across this advert on FB. I don't plan on trying it. Seems the PT141 dose is so low as to be useless and administered orally. But it looks like vendors are trying to make cocktail ED pills now. https://nuimagemedical.com/enroll?progr ... =2&sub1=fb
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

Flavio
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Re: PT-141 (Bremelanotide)

Postby Flavio » Tue Mar 09, 2021 1:16 pm

Stew52 wrote: [...] But it looks like vendors are trying to make cocktail ED pills now.[...]


Absolutely!

I've been advocating cocktail pills for years, ED is a multifactorial condition and combination therapy is the logical step to take.

What are your thoughts on oral PT-141 and especially the Mt. Everest tablets?

Mt. Everest is a brilliant find, thank you for sharing this.
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

passerarf
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Re: PT-141 (Bremelanotide)

Postby passerarf » Tue Mar 09, 2021 11:21 pm

Also very curious to hear about the Mt. Everest tablets!

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Stew52
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Location: Central TX

Re: PT-141 (Bremelanotide)

Postby Stew52 » Wed Mar 10, 2021 9:27 am

Flavio wrote:
Stew52 wrote: [...] But it looks like vendors are trying to make cocktail ED pills now.[...]


Absolutely!

I've been advocating cocktail pills for years, ED is a multifactorial condition and combination therapy is the logical step to take.

What are your thoughts on oral PT-141 and especially the Mt. Everest tablets?

Mt. Everest is a brilliant find, thank you for sharing this.


Normally PT141 is injected into belly fat. Not oral. The injectable dose is 1-2 mg typically (1000-2000mcg). I have no idea how the same dose (1000mcg) in an oral would work. And for me, oxytocin had no apparent effect. So I'm a bit dubious about this. Hope it works for you. B
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

ETGuy71
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Location: Texas

Re: PT-141 (Bremelanotide)

Postby ETGuy71 » Wed Mar 10, 2021 10:37 am

I have the Mt. Everest tablets. I got them to try the “cocktail”!
For me, I had little observable change. Actually no different than just taking 20mg of Cialis.
Which I get only marginal results from, this is why I’m on Trimix!
Not saying this blend won’t work great for someone else, but it did not for me.
Diagnosed venous leak. Going with injections rather than implant for the time being.

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Stew52
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Location: Central TX

Re: PT-141 (Bremelanotide)

Postby Stew52 » Fri Mar 19, 2021 6:13 pm

I used the last 1.1mg in the bottle. From earlier experience since the delay is so long, I shot myself in at 10;00PM for a beneficial reaction 4-14 hours later with a sweet spot at 10-12 hours out. This really takes advance planning and a date/time certain for playtime. The usual effects: flushed face and burning eyes at 10 min, heavy pulse at 15 min, and some nausea setting in in 20 min. At 1.1mg it's unpleasant - especially when trying to get to sleep - but tolerable. It was NOT tolerable at 2.5mg (see above); it was wild and wooly. Awoke at 02:30 am with a 90% erection, not enough for sex but good PT. These continued off and on to 10 1/2 hours out at 8:30AM. Mild nausea in AM. The effect wore off quickly after 08:30AM. The beneficial period was shorter and less pronounced than the last 1.5mg and a lot less than the high voltage 2.5mg. I still have a 10mg bottle to mix up and play with. At 1.5mg the effects are about right but delayed and requires shooting up before bed to take effect the next day AM, like 8-12 hours. I guess you could shoot up in the AM and play in the evening but we are not evening sex people. Thoughts?
NOT an MD. 71, M51 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.

Flavio
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Re: PT-141 (Bremelanotide)

Postby Flavio » Fri Mar 19, 2021 6:33 pm

ETGuy71 wrote:I have the Mt. Everest tablets. [...]


Are these sublingual tablets?

I'm guessing that oral PT-141 is ineffective because it doesn't cross the blood brain barrier but maybe a sublingual tablet could do the trick? Just asking.
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.

ETGuy71
Posts: 307
Joined: Thu Jul 19, 2018 10:58 pm
Location: Texas

Re: PT-141 (Bremelanotide)

Postby ETGuy71 » Sat Mar 20, 2021 12:21 pm

Flavio, I haven’t noticed anything stimulate wise taking the sublingual PT141!
So I’m thinking your thought on the ability to cross the blood brain barrier is very like valid.
Diagnosed venous leak. Going with injections rather than implant for the time being.


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