SO I went though a 10mg vial (in 1 ml biostatic water, 1mg = 10 units) over the past 2 1/2 weeks (10/4-20) to figure this stuff out. Some sites say to use as needed, some every 2 days, and where I bought it from says every 4 days (@ 1.75mg). As an aside, I find it curious that some sites say it is effective for ED after an hour and other sites say use it every 2 or 4 days. One site says increase from 1 mg to 4 mg to find your sweet spot and others say to increase to 1mg and others 1.75mg with no ramp up. The info seems to be all over the place. So I started slow and careful and took notes.
I ramped up about every 2-3 days as follows: 0.5mg, 0.5mg, 0.75mg, 0.75mg, 1.0mg, 1.2mg, 1.5ng, 1.8mg, 1.8mg.
Side effects: generally started in 5-10 minutes, peaked at 1-2 hours, and mostly subsided in 4-6 hours. Sites say the most common side effect is nausea. I’d say it’s more like a pretty upset stomach with a hint of nausea and moderate reflux, enough that I popped some Tums. This went on for hours. The worse effect for me was flushing. I looked red, my face felt hot. My eyes were mildly bloodshot and burnt. This went on for 2 hours. My sinuses and nose got very stuffy and runny, like a histamine reaction. I hit each side with a shot of Afrin and an antihistamine spray. This went on for a couple of hours. My pulse got heavy for a while, I had an anxious feeling, and my BP was mildly raised. I seemed to be a bit light-headed. For the mostl part I just felt YUCKY. It kinda felt like a histamine reaction. All this such that I could not see having sex for 5 or so hours, and certainly not within “2 hours” The side effects got worse as dose was increased save the first small dose which was bad. I would call the side effects for me at 1.8mg as moderately bad. The better part of a day is shot feeling like you are getting the flu.
Effects: First, my dose by some accounts was mid-range so this evaluation is incomplete. I have bought more to test higher doses and will report then. Overall benefits seemed vague/elusive and mild. First, I have no problem with libido. I could jump the shark a couple times a day (68 y/o) wife willing (but she’s not). I have Anorgasmia so there is no refractory period). So I was NOT looking for that benefit AND I did not detect any increase in libido. I did have a mild stirring/tickle in my loins on occasion the 2nd day, stronger in the first 24 hours. Nocturnal tumescence and morning wood was enhanced (taking 5 mg Cialis for PT) on the 2nd day and actually disruptive to sleep. Several times I did have “stirrings” and a partial erection with some at random inopportune times. It was brought on by thought and casual contact. BUT it did not hold for long. We had sex 5 times during this trial period and tried without TriMix injections and it was not very successful and always required a shot to perform. So at 1.8mg it did not help my ED. And as well during this period I had no ejaculation during sex, so it did not help anorgasmia.
Conclusion: My first blush is that the benefits FOR ME do not outweigh the “cost” (at 1.8mg every 2-3 days). But I am willing to try higher doses, if tolerated. Why? I am intrigued by the instances of increased tumescence and by the occasional erections. And, I’d like to hope that I can decrease the amount of TriMix I need, and also improve the anorgasmia problem. Perhaps longer-term use brings better benefits. I am not looking forward to side-effects at higher doses. Appreciate your suggestions.
NOT an MD. 68, M48 yrs, CenTX US. Inj since 12/16 a yr after pills stopped working. Caverject for a yr. 1/18 Tri-Mix at 30 pap/2 phent/40 pge @0.3ml supp w/0.1-0.2ml 60mcg/ml PGE1 on occasion for a longer session. DE/Anorgasmia setting in since 5/19