Tolerance for PDE5 over the years

Anything goes when it comes to ED.
Canuck67
Posts: 117
Joined: Sun Oct 20, 2019 11:05 pm

Tolerance for PDE5 over the years

Postby Canuck67 » Wed Nov 04, 2026 8:54 am

I have been using Pde5, Viagra, cialis and levitra over 25 years.

Started with Viagra it worked good at low doses for years then I develop side effect as back aches and headaches.

Switched to Cialis which was perfect with very low side effect then I started to have back aches and other side effects.

Came back to Viagra which worked good again with low side effect until i develop side effect again.

Tried Levitra , same thing it was perfect at first then after a while the muscular and back aches were too much.

Back to Cialis for a while but it now gives me back and stomach aches.

Using some viagra now that worked perfect at first with little side effects but now Im getting a lot of acid reflux and back aches again.

Tried Trimix for a while it worked really good but im getting the same side effects as Pde5 pills.

Dont know were to go from here, Pde5 all works at higher doses but the side effects are too strong and im not ready for an implant.
59 years old. Using Cialis or Viagra with Good/mix results with the bad side effects. Started Trimix 05/2026. Trimix 10-1-30 mix.

mrksman
Posts: 50
Joined: Wed Jan 19, 2022 11:14 pm

Re: Tolerance for PDE5 over the years

Postby mrksman » Wed Nov 04, 2026 12:10 pm

In your Bio it looks like you have tried Tri-Mix. How is that working out for you?
Age 60, happily married over 40 years. Take daily Cialis, supplemented with Levitra before sex. Also use a Vacurect VED with a Pos-T-Vac Mach Ring. Still trying to get TRT dialed in.

Canuck67
Posts: 117
Joined: Sun Oct 20, 2019 11:05 pm

Re: Tolerance for PDE5 over the years

Postby Canuck67 » Wed Nov 04, 2026 1:46 pm

Trimix works good but I have the same side effect as the pde5.

Headaches, backaches same, everybody said no side effect with injections but thats not my case.
59 years old. Using Cialis or Viagra with Good/mix results with the bad side effects. Started Trimix 05/2026. Trimix 10-1-30 mix.

ready2go
Posts: 869
Joined: Fri Aug 25, 2023 7:47 pm

Re: Tolerance for PDE5 over the years

Postby ready2go » Wed Nov 04, 2026 6:43 pm

i was using tadalafil from india . 80mg per pill which i cut into quarters .
it worked well ,i took it up to 64 years of age .
but i also started to have issues being able to swallow , and even had spasims , triggerd when eating . once they would not stop .and went to the ER . they gave me muscle relaxer to stop it . i had not thought that issue could be connected to the tadalifil .
it also gave me severe heart burn , besides the good hard erections .
so much that in the middle of the night i would get out of bed and kneel down to try to ease the heartburn .
when i stopped taking the tadalifil both issues went away
now i have a malleable so i dont need pd5's for an erection but have tried generic viagra for added girth engorgment . that has not given me any issues so far , knock on wood . but only tried that once so far .
i also did injections . not tri mix ,just one ingredient . it worked good when i got the injection right . i didnt notice any side effects .
but fock that sticking a needle there . besides it leads to scarring . and if you are out looking to get some ,are you going to bring a siringe with you ,etc ?
if you married AND you both plan on getting down AND set a time , then it would be sort of ok . but the whole ordeal was to much for me .
American , retired in the philippines .
tactra malleable 13 mm ,in new delhi India . march 2024


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