Question regarding taking sildenafil AND Tadalafil together

Anything goes when it comes to ED.
Never_Enough
Posts: 242
Joined: Fri Nov 24, 2023 7:54 am

Question regarding taking sildenafil AND Tadalafil together

Postby Never_Enough » Sun Mar 29, 2026 11:43 am

Something I've never been able to get a clear answer to on Reddit and other places because people seem to misconstrue the question.

Every online and basic medical resource seems to indicate you shouldn't mix both pde5s.

However they also say that other than duration and onset they work in the same way.

Given this to be the case why should taking 50 mg sildenafil and 10 mg tadalafil be any different to taking 100 sildenafil or 20 mg tadalafil?

Bearing in mind I'm not talking about taking both at maximum doses or taking over what woukd be the maximum dose of one combined, but taking a combination like 25 mg sild and 15 mg tad or 5 mg tad and 50 mg sild.

Is there any reason why it should be more dangerous than taking the full dose of one?

Thanks.
39 m UK

Psych ED since forever less problems being erect alone.
3 kids. Long term partner.
CPPS pudendal neuralgia and muscle tightness in late 2023 making ED worse.
Cialis no longer works. Sildenafil 100mg with diazepam works some of the time.

CanGetItUpButNotOff
Posts: 463
Joined: Mon Sep 20, 2021 1:34 pm

Re: Question regarding taking sildenafil AND Tadalafil together

Postby CanGetItUpButNotOff » Sun Mar 29, 2026 4:47 pm

I've moved on to ICI and no longer take Sildenafil; I still do take a daily 10ng Tadalafil for general health more than ED. But my urologist was a fan of combining the two PDE5's. Tadalafil at a low-dose daily and Sildenafil on demand.
Born 1954. Diabetes, hypertension, atherosclerosis. Sildenafil iffy. Tri-Mix 30/3/20 Pap/Phen/PGE1 godsend pending long-term efficacy. Daily Cialis. Tried LiESWT 4 times, Botox, PT141, Eroxon, QST, DUS, Vertica, Ferticare, cabergoline, psycho+hypnotherapy


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