PT-141 and Melanotan 2

Anything goes when it comes to ED.
Budward
Posts: 87
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: PT-141 and Melanotan 2

Postby Budward » Thu Jun 06, 2024 12:38 pm

CanGetItUpButNotOff wrote:I'm seeing an aggressive urologist for my increasing ED and delayed ejaculation that is trending toward outright anorgania. Jointly, we both were skeptical about any benefit from Bremelanotide (a/k/a PT-141), but I saw a report from last month's AUA conference that Dr. Irwin Goldstein found some success. Link: https://www.medpagetoday.com/meetingcoverage/aua/110009 or https://www.auajournals.org/doi/10.1097 ... 4863.1b.03

My doc approved but did not have sources for Bremelanotide, so I went Internet searching. I came up with:

https://precisionpeptideco.com/
https://www.peptidepros.net/product/pt-141/
https://www.limitlesslifenootropics.com
https://purerawz.co/

I'd appreciate any comments on the reliability, or more importantly, quality of PT-141 from these suppliers.

I ordered one or two 10mg bottles from each. Prices varied depending on quantity, shipment, payment terms, etc, but ranged from (USD) $37 to $62.

As you can see, I'm going to go all-in to see if this is the miracle cure ;) I'm looking for to make sex more enjoyable and reliable. To date, shockwave plus Sildenafil and Tadalafil have helped with the ED. I take Cabergoline for the DE but I don't see much improvement. Any boost in orgasmic response will make it worthwhile. If not, I'll move on to the next thing.


I didn't have any luck with Purerawz. I did have luck with Pharmalabglobal out of the UK. Also not impressed with https://biosynergen.com/

CanGetItUpButNotOff
Posts: 18
Joined: Mon Sep 20, 2021 1:34 pm

Re: PT-141 and Melanotan 2

Postby CanGetItUpButNotOff » Thu Jun 06, 2024 4:44 pm

Budward wrote:
I didn't have any luck with Purerawz. I did have luck with Pharmalabglobal out of the UK. Also not impressed with https://biosynergen.com/

Thanks, Did PureAWZ not even deliver or did the product not work for you?

Budward
Posts: 87
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: PT-141 and Melanotan 2

Postby Budward » Wed Jun 12, 2024 12:01 pm

CanGetItUpButNotOff wrote:
Budward wrote:
I didn't have any luck with Purerawz. I did have luck with Pharmalabglobal out of the UK. Also not impressed with https://biosynergen.com/

Thanks, Did PureAWZ not even deliver or did the product not work for you?

Pureraws delivered but the stuff didn't work. To be fair it took a long time to arrive and the powder in the vials was not compacted at the end of the vial but was spread around the vial like a sandcastle. Perhaps it arrived in bad shape.

Jayguy
Posts: 30
Joined: Tue Dec 13, 2022 1:29 pm

Re: PT-141 and Melanotan 2

Postby Jayguy » Tue Jun 18, 2024 2:27 pm

I'm in my 60's and have successfully used PT -141. I ordered mine from biotechpeptides.com. It comes in 10mg powder form to which I add 1ml of bac water to form the solution. From there I inject 15 units sub q with a U100 1ml syringe into the abdomen. I inject around 1-2 pm for sex after 8 pm. The effects also last to the next morning. Works every time for me (fortunately). I use it in conjunction with trimix for a longer lasting erection and a much stronger libido (temporary effects).
Birth Year 1959, Happily married to wife since 1987. On TRT since age 45, started sildenafil at age 48. Had lifesaving abdominal surgery at 61 with lost erectile function following surgery. Started trimix in January 2023 at age 63.

wolfpacker
Posts: 1028
Joined: Thu Dec 12, 2013 10:16 pm

Re: PT-141 and Melanotan 2

Postby wolfpacker » Tue Jun 18, 2024 2:57 pm

Jayguy wrote:I'm in my 60's and have successfully used PT -141. I ordered mine from biotechpeptides.com. It comes in 10mg powder form to which I add 1ml of bac water to form the solution. From there I inject 15 units sub q with a U100 1ml syringe into the abdomen. I inject around 1-2 pm for sex after 8 pm. The effects also last to the next morning. Works every time for me (fortunately). I use it in conjunction with trimix for a longer lasting erection and a much stronger libido (temporary effects).


What size is the needle you use?
Early 30s with ED for years from penis enlargement stretching and jelqing. Implant by Dr Eid on 24 June 2021 with a Titan 24cm with +1cm RTE on one side and -1cm cut off on the other side

My journal: viewtopic.php?t=17202

CanGetItUpButNotOff
Posts: 18
Joined: Mon Sep 20, 2021 1:34 pm

Re: PT-141 and Melanotan 2

Postby CanGetItUpButNotOff » Tue Jun 18, 2024 5:58 pm

Jayguy wrote:.... Works every time for me (fortunately). I use it in conjunction with trimix for a longer lasting erection and a much stronger libido (temporary effects).
If you have any issues with delayed ejaculation or anorgasmia, does the PT-141 help with those?

Big_one67
Posts: 2
Joined: Mon Feb 26, 2024 7:15 am

Re: PT-141 and Melanotan 2

Postby Big_one67 » Tue Jun 18, 2024 6:26 pm

Hi everyone, I have tried pt141 4 times with good results and I would be curious to also try melatonan 2, my problem is that I have many moles and I have read that the use of melatonan 2 can favor the appearance of melanomas. What do you think?

Jayguy
Posts: 30
Joined: Tue Dec 13, 2022 1:29 pm

Re: PT-141 and Melanotan 2

Postby Jayguy » Wed Jun 19, 2024 5:01 pm

Canget and Wolfpacker - I use a 1/2" long 27 to 31 guage needle. The PT141 solution is pretty thin so it draws and injects easily. Remember, PT is a sub cutaneous (subq) injection so a 1/2 length needle is prefect for me. As for anorgasmia/delayed ejac... The PT 141 helped with the anorgasmia that I occasionally get with trimix but I still had to work for the orgasm.
Birth Year 1959, Happily married to wife since 1987. On TRT since age 45, started sildenafil at age 48. Had lifesaving abdominal surgery at 61 with lost erectile function following surgery. Started trimix in January 2023 at age 63.

CanGetItUpButNotOff
Posts: 18
Joined: Mon Sep 20, 2021 1:34 pm

Re: PT-141 and Melanotan 2

Postby CanGetItUpButNotOff » Thu Jun 20, 2024 2:21 pm

Here's a report on my first try with PT-141. I bought several from different suppliers - the first I mixed was from Xcel Peptides ( https://www.xcelpeptides.com/product/pt-141/). I bought bacteriostatic water separately and injected 1ml into the 10mg bottle. I noticed the rubber seal was hard to penetrate with the water hypodermic needle; I almost feared breaking the needle.

With no sex on the horizon for the first evening (but hopeful for the next morning), I decided to try just 1mg (i.e. .1ml or 10iu) at 6pm to see what reaction my body had. It was probably a bad time to experiment since I was feeling the effects of a mild cold and some existing lower back pain. But after taking the 1mg of PT-141, my back pain was considerably worse. I'm hesitant to blame the PT-141, especially since it was such a low dose, but it's worth noting. My cold symptoms also became worse, turning into lethargy. I noticed no nausea but also no increase in libido or erections.

There are some reports of positive effects lasting 24+ hours so I was hopeful for lingering positive results the next morning. At 10am, with mid-day sex imminent, I took another 1mg shot (the combination getting to my target dose of 2mg, albeit with a 16 hour delay). I take a daily 10mg Tadalafil and now I added a 50mg Sildenafil. The combination of the two PDE-5 inhibitors is usually, but not always, sufficient to sustain an erection for intercourse so the effectiveness of the PT-141 is impossible to gauge. My main reason for taking the PT-141 is for anorgasmia, not erections. The result was a satisfactory erection, penetration and orgasm. Whether the PT-141 helped is hard to say. Another factor was a 5-day refractory period which usually helps the anorgasmia. Notwithstanding the back pain the night before, the 2mg (spaced 16 hours apart) did not give me any nausea or other intolerable symptoms so I am ready to try a more conventional protocol of 2mg a couple of hours before sex. I may go without the Sildenafil to see how Tadalafil + PT-141 works.

I'd appreciate any comments.

EDIT: Try #2. This time I injected 2mg of PT-141. I quickly felt some slight flushing and slight pressure around my eyes. My normal regimen is, when I have advance notice, to supplement daily 10mg Tadalafil with 50mg Sildenafil an hour before sex. This time I skipped the Sildenafil and relied solely upon the daily Tadalafil and PT-141. Two hours after the PT-141 shot, the fun began. I was feeling no effects from the shot - either positive or negative. My erection was good but I can't say whether that was from the Tadalafil or some extended fun foreplay or the PT-141. It had been a 3-day refractory period which is usually marginal so I was happy for the sustained erection, whatever the cause. Again, in light of the 3-day refractory period, I was pleased with my ability to ejaculate pretty much when I wanted to. (In the past, extended intra-vaginal time would take me past the peak and I would either lose the erection or be unable to cum.) So, once again, I'm not seeing any illl-effects from the PT-141 and while things worked out well, I can't see any direct connection between the PT-141 and the successful outcome. I'm definitely, now 18 hours past the injection, not experiencing raging libido or non-stop erections.

Budward
Posts: 87
Joined: Thu Feb 01, 2024 5:12 pm
Location: BC Canada

Re: PT-141 and Melanotan 2

Postby Budward » Thu Jul 04, 2024 12:14 pm

I think I may have started this thread and was a very big advocate of these peptides. Yesterday I completely changed my opinion. After a dose of Melanotan 2, I became highly nauseated. I vomited all day long, couldn't eat or drink even a sip of water. My wife wanted to take me to the hospital. Please be very careful with your dosing. I took a bit over .2 and I should have only taken .05.

I just jettisoned the remaining peptides, just not worth it. Don't need it, I will stick to Trimix for when I have sex.

Sorry for being so high on this and recommending, if you use start very low and see where you go.


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