FrankTalk.org

From some data I compiled from notes:
2000 - started using pills (48 y/o)
12/2016 - started using Caverject, 20-40 mcg
2/2018 - started using TriMix, similar PGE strength
4/2018 - first Delayed Ejaculation vaginally
* continued using mostly TriMix and some MonoMix (4-7/2018)
* continued to worsen
5/2019 - last ejaculation vaginally
* it's even getting harder to get a "manual" ejaculation
7/2020 - back to MonoMix

Thoughts:
A. Clearly pills up to 100mg Viagra had no immediate effect in 16 years (or maybe LT use)
B. 1 1/2 yrs of Caverject (PGE) had no immediate effect (again, maybe LT use)
C. 2 mos after starting TriMix had 1st vaginal DE, worsened to none over 13 mos with TriMix

And . . . .
Switched back to MonoMix 7/2020 and no noticeable DE improvement (yet, but at a lower dose with PT),
Added 5 mg Cialis 8/2020 occasionally and daily 10/2020, and no DE change (but other benefits),
Tried Oxytocin losenges in 9/2020 and no noticeable DE change
Started more regular "penile PT" 9/2020 with no noticeable DE improvement (but other benefits)
Added Wellbutrin 11/2020 and no noticeable DE change
Testing PT141 starting 11/2020 - still in progress
Possibly test/try Cabergoline?

I honestly think my DE is just aging Peripheral Neuropathy (I have it advancing in my feet for several years now) but the connection to starting TriMix (2 mos later) is hard to ignore but clearly not a rigorous test (double-blind placebo-controlled and all that jazz)

See this thread: viewtopic.php?f=5&t=13424

That's interesting. My experience could associate alprostadil and DE but I'll never know. After my RRP I was pretty much unable to reach climax flaccid by any means. With VED and rings it was exceedingly difficult and rare vaginally. With injections it's also exceedingly difficult and rare vaginally. I'm thinking my sensitivity was damaged as a result of the RRP (in margins). It was supposed to be nerve sparing but it obviously wasn't. Age could also be a factor as could mild Type 2. Who knows?

I wish you the best in chasing a solution. Please let me know if you find the magic bullet.