Clomipramine HCL???

One out of Three men in America suffer with PE. It's the largest sexual dysfunction there is. Since there is no discussion board dedicated to PE so far, we will try to fill the need here!
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Clomipramine HCL???

Postby Seeker82 » Thu Jan 27, 2022 6:00 pm

Hello to the community!

I've suffered from severe PE my whole life and it has greatly impacted my dealing with women. I've been looking for help online and it's hard to know what will work for me but I know for sure that these "edging" and "start/stop" techniques don't work (for me). When I say severe I mean I can't last a second...I ejaculate upon penetration.

I've never told anyone as it is so embarrassing. Out of desperation and wanting to be able to be in a relationship and have intercourse with my partner, I sought help from a men's health clinic in my area. The doctor prescribed Clomipramine HCL (brand name: Anafranil). I took it once but did not like the way it made me feel. The doctor indicated that I need to take it regularly for it to work. At this point I'm so desperate to be rid of this condition that I'm willing to bite the bullet if it means I'll get better.

Has anyone taken this medication before and what was your experience with it? Did it help? How much were you taking? For how long? Etc...

Any other info would help as well, in terms of other meds or doctor recommendations.

Thank you in advance

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Re: Clomipramine HCL???

Postby bldoink » Thu Jan 27, 2022 7:45 pm

I have no experience with the drug or PE. I have more the opposite problem.

Here is one study on the drug that's about 25 years old: One thing that stood out to me was "Clomipramine inhibited nocturnal penile tumescence in all subjects." There are links to related articles at the bottom of the study. I didn't read any of them.

Good luck.
R.R.P 2011 Mayo Jacksonville, Dr. Michael Wehle. Nerve sparing - badly damaged. C in margin. V.E.D, Viagra and PGE-1 (80mcg/ml) injections @ ~ 14 units. Originally Edex20, then compounded PGE-1 - cost. Inject. 10+ yrs. It works. Treasure coast of FL.

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Re: Clomipramine HCL???

Postby BearsWin » Sat Feb 25, 2023 8:35 pm

This is an old school antidepressant. I think the other options out there now (the well known SSRIs) are better for all things, whether depression, anxiety or PE.
Born 1966. PDE-5s since age 40. Decreasing efficacy age 50. Started on Trimix 2022 - variable response even at high doses. Coloplast Titan 11/1/22 Dr. Yafi UCI, submuscular/ectopic reservoir. History of hypertension. Married, Nevada.

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Re: Clomipramine HCL???

Postby alfa88 » Sun Feb 26, 2023 6:00 pm

A previous post mentioned Paroxetine. It looks to be more effective than the sertralineI take but it's not advisable for those over 60. Lets me out. With sertraline sometimes I can last forever but most times 5 -15 .
53 years old, married 32 years. Decades of ED & PE. BPH. Tried Viagra W & W/O T-Shots, Levitra and Cialis, Edex, Trimix starter, medium, strong with poor results, VED. Implanted w/AMS700CX 21cm X 12mm w/1.5cm RTE by Dr. Leroy Jones 9/1/20

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